Publications by authors named "Michael Syrett"
Low back pain (LBP) is a globally prevalent and costly societal problem with multifactorial etiologies and incompletely understood pathophysiological mechanisms. To address such shortcomings regarding the role of neurotrophins in the underlying mechanisms of pain, an LBP model was developed in rats involving two unilateral intramuscular injections of nerve growth factor (NGF) into deep trunk muscles. To date, behavioral investigations of this NGF-LBP model have been limited, especially as it pertains to female pain behaviors.
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- Low back pain (LBP) is a significant global issue, and a new rat model using nerve growth factor (NGF) injections has been created to study its effects.
- The study tracked the development of sensitivity to mechanical stimuli in both the trunk and hindpaw of male rats over time, revealing increased sensitivity in the trunk region after NGF injections, with delayed hypersensitivity compared to deep muscle pain.
- These findings suggest that the somatosensory changes mainly occur locally in the area of the NGF injection, differing from previous studies on female rats, prompting future research into potential sex differences in pain response.