Publications by authors named "Michael Suess"
The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). However, molecular details of isoform-specific PR-CoR interactions remain poorly understood.
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- The progesterone receptor (PR) has two isoforms, PR-A and PR-B, which play different roles in reproductive tissues, and their imbalance is linked to breast cancer.
- This study used structural mass spectrometry to explore how PR interacts with co-regulatory proteins SRC3 and p300, revealing new binding details and changes during complex assembly.
- The findings challenge existing models of how nuclear receptors function, offering insights into the activation mechanisms of PR when bound to various ligands.