Publications by authors named "Michael Ska"
Article Synopsis
- The study investigates the effectiveness of two vaccine candidates, AdC7-GRN (a chimpanzee adenovirus) and F4/AS01 (a recombinant fusion protein), in generating immune responses against HIV-1 in both macaques and mice.
- Results indicate that heterologous prime-boost regimens (combining both vaccines) produce stronger and more sustained CD4+ and CD8+ T-cell responses than homologous regimens, particularly in macaques.
- The combination of these vaccines not only stimulates high-frequency, antigen-specific T-cell responses but also leads to the production of HIV-1-specific antibodies, showing potential for improved HIV-1 control strategies.
