Publications by authors named "Michael Selorm Avumegah"
Objective: To evaluate the long-term humoral immune response to Nipah virus (NiV) in a cohort of 25 survivors after 25 years of post-infection.
Methods: A total of 25 survivors of NiV infection from the 1998 outbreak were recruited for sample collection. The serum IgG antibody response to NiV antigens, specifically nucleocapsid (N), fusion glycoprotein (F) and attachment glycoprotein (G) was evaluated using ELISA.
Article Synopsis
- * Despite their importance, current RDTs suffer from limitations in clinical sensitivity and specificity, require significant funding for development, and struggle with implementation, especially in low-income countries due to insufficient investments and competing health priorities.
- * The recent World Health Assembly resolution highlights the need for enhanced diagnostic capabilities, but it lacks binding power, making it crucial to seek funding mechanisms like the Pandemic Fund to improve RDT development for better pandemic preparedness.
Reference materials are critical in assay development for calibrating and assessing their suitability. The devasting nature of the COVID-19 pandemic and subsequent proliferation of vaccine platforms and technologies has meant that there is even a greater need for standards for immunoassay development, which are critical to assess and compare vaccines' responses. Equally important are the standards needed to control the vaccine manufacturing processes.
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