Development of Critical-size Abdominal Defects in a Rabbit Model to Mimic Mature Ventral Hernias.

Background/aim: Mesh hernioplasty is one of the most frequently performed procedures in the United States. Abdominal rigidity and chronic inflammation, among other factors, contribute to long-term complications including chronic pain, abdominal wall stiffness and fibrosis. Acute models do not replicate the chronic environment associated with most hernias, limiting the ability to improve products.