Correction: Schütt et al. Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model. 2022, , 184.

In the original publication [...

Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model.

The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in vitro model of the human proximal colon.

Modelling and Simulation of the Drug Release from a Solid Dosage Form in the Human Ascending Colon: The Influence of Different Motility Patterns and Fluid Viscosities.

For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug dissolution. Commonly, the performance of a drug formulation is assessed using standardised dissolution apparatus, which does not replicate the hydrodynamics and shear stress evoked by wall motion in the colon. In this work, computer simulations are used to analyse and understand the influence of different biorelevant motility patterns on the disintegration/drug release of a solid dosage form (tablet) under different fluid conditions (viscosities) to mimic the ascending colonic environment.

Unconventional Multiband Superconductivity in Bulk SrTiO_{3} and LaAlO_{3}/SrTiO_{3} Interfaces.

Although discovered many decades ago, superconductivity in doped SrTiO_{3} remains a topic of intense research. Recent experiments revealed that, upon increasing the carrier concentration, multiple bands cross the Fermi level, signaling the onset of Lifshitz transitions. Interestingly, T_{c} was observed to be suppressed across the Lifshitz transition of oxygen-deficient SrTiO_{3}; a similar behavior was also observed in gated LaAlO_{3}/SrTiO_{3} interfaces.

Exploring the needs of certified hand therapists regarding electronic applications.

Study Design: Survey.

Introduction: App technology may provide a beneficial clinical resource for CHTs.

Purpose Of Study: This descriptive study examined beneficial components for inclusion in a potential app for certified hand therapists to use as a clinical resource based on a nationwide survey.

Antagonistic In-Plane Resistivity Anisotropies from Competing Fluctuations in Underdoped Cuprates.

One of the prime manifestations of an anisotropic electronic state in underdoped cuprates is the in-plane resistivity anisotropy Δρ≡(ρ(a)-ρ(b))/ρ(b). Here we use a Boltzmann-equation approach to compute the contribution to Δρ arising from scattering by anisotropic charge and spin fluctuations, which have been recently observed experimentally. While the anisotropy in the charge fluctuations is manifested in the correlation length, the anisotropy in the spin fluctuations emerges only in the structure factor.