Publications by authors named "Michael Schonning"

Failure in the elongation of the cardiac outflow tract (OFT) results in congenital heart disease due to the misalignment of the great arteries with the left and right ventricles. The OFT lengthens via the accretion of progenitors from the second heart field (SHF). SHF cells are exquisitely regionalized and organized into an epithelial-like layer, forming the dorsal pericardial wall (DPW).

View Article and Find Full Text PDF

Background: Supersaturated oxygen (SSO) delivered into the left anterior descending coronary artery after percutaneous coronary intervention (PCI) for anterior ST-segment elevation myocardial infarction (STEMI) has been shown to reduce infarct size, but its effects on microvascular obstruction (MVO) are unknown. The aim of this study was to compare MVO in patients with anterior STEMI treated with SSO after successful primary PCI from 2 studies (the optimized SSO pilot and IC-HOT) with similar patients from 7 randomized trials who underwent primary PCI without SSO treatment.

Methods: A total of 874 patients with anterior STEMI who underwent MVO assessment using cardiac magnetic resonance imaging within 10 days after primary PCI were included, of whom 90 patients (10.

View Article and Find Full Text PDF
Article Synopsis
  • Anemia is common among patients with cardiovascular disease, particularly those undergoing high-risk percutaneous coronary intervention (HRPCI) with Impella support, and is linked to worse outcomes.
  • The study evaluated patients' hemoglobin levels to categorize them into no anemia, mild anemia, and moderate/severe anemia, revealing that anemic patients tended to be older and had more health issues.
  • Results showed that anemia significantly increased rates of major adverse cardiovascular events and major bleeding at 30 and 90 days, highlighting the need for focused strategies to manage anemia's impact on patient outcomes after HRPCI.
View Article and Find Full Text PDF

Background: Infantile hemangiomas (IHs) are benign endothelial cell (EC) tumors that undergo a predictable natural history, with rapid proliferation, stabilization, and involution. However, mechanisms regulating these transitions are not well understood. We have observed loss of vascular endothelial cadherin (VECAD) in involuting/involuted IHs.

View Article and Find Full Text PDF

This study addresses the potential to reverse age-associated morbidity by establishing methods to restore the aged hematopoietic system. Parabiotic animal models indicated that young secretome could restore aged tissues, leading us to establish a heterochronic transwell system with aged mobilized peripheral blood (MPB), co-cultured with young MPB or umbilical cord blood (UCB) cells. Functional studies and omics approaches indicate that the miRNA cargo of microvesicles (MVs) restores the aged hematopoietic system.

View Article and Find Full Text PDF

Venous malformations (VMs) are slow-flow malformations of the venous vasculature and are the most common type of vascular malformation with a prevalence of 1%. Germline and somatic mutations have been shown to contribute to VM pathogenesis, but how these mutations affect VM pathobiology is not well understood. The goal of this study was to characterize VM endothelial and mural cell expression by performing a comprehensive expression analysis of VM vasculature.

View Article and Find Full Text PDF

Rationale: Defects in the morphogenesis of the fourth pharyngeal arch arteries (PAAs) give rise to lethal birth defects. Understanding genes and mechanisms regulating PAA formation will provide important insights into the etiology and treatments for congenital heart disease.

Objective: Cell-ECM (extracellular matrix) interactions play essential roles in the morphogenesis of PAAs and their derivatives, the aortic arch artery and its major branches; however, their specific functions are not well-understood.

View Article and Find Full Text PDF
Article Synopsis
  • - Infantile hemangioma (IH) is a type of vascular tumor that rapidly grows after birth and shrinks during early childhood, with NOTCH3 playing a key role in the differentiation of stem cells involved in this process.
  • - NOTCH3 is found in both hemangioma stem cells (HemSCs) and endothelial cells during the proliferative phase of IH, but its expression shifts to mural cells in the involution phase.
  • - Inhibition of NOTCH3 in HemSCs disrupts the normal development of mural cells and vascular stability, indicating its critical role in the differentiation and maintenance of blood vessels in IH.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: