Publications by authors named "Michael Schoerghuber"
Article Synopsis
- The study aimed to investigate the impact of following guideline-recommended withdrawal periods of P2Y12 receptor inhibitors before on-pump coronary artery bypass grafting (CABG) on bleeding and ischemic events, noting a lack of randomized controlled trials in this area.
- Researchers analyzed data from 7 observational studies involving 4,837 patients who underwent CABG, measuring severe bleeding (BARC-4) and postoperative ischemic events.
- Results indicated that adhering to suggested withdrawal times significantly reduced the risk of severe bleeding for clopidogrel users while showing a similar trend for ticagrelor, with no significant change in 30-day mortality but a decrease in ischemic events for clopidogrel users.
Background: Major cardiac surgery related blood loss is associated with increased postoperative morbidity and mortality. Platelet dysfunction is believed to contribute to post-cardiopulmonary bypass (CPB)-induced microvascular bleeding. We hypothesised that moderately hypothermic CPB induces platelet dysfunction and that supplemental fibrinogen can restore in vitro thrombus formation.
View Article and Find Full Text PDFIntroduction: In order to reduce the risk of bleeding in patients on P2Y receptor inhibitors presenting for non-emergent coronary artery bypass grafting (CABG), current guidelines recommend a preoperative discontinuation period of at least three, five and seven days for ticagrelor, clopidogrel and prasugrel, respectively, to allow for recovery of platelet function. However, there is still substantial interinstitutional variation in preoperative management and relevant covariates of CABG-related bleeding are largely elusive so far.
Methods And Analysis: We will search PubMed (July 2013 to November 2021) and EMBASE (January 2014 to November 2021) using the following terms, MeSH terms and their synonyms: clopidogrel, prasugrel, ticagrelor, dual antiplatelet, P2Y receptor inhibitor, CABG, bleeding, haemorrhage.
Background: Coronavirus disease 19 (COVID-19)-associated pulmonary aspergillosis (CAPA) emerged as important fungal complications in patients with COVID-19-associated severe acute respiratory failure (ARF). Whether mould active antifungal prophylaxis (MAFP) can prevent CAPA remains elusive so far.
Methods: In this observational study, we included all consecutive patients admitted to intensive care units with COVID-19-associated ARF between September 1, 2020, and May 1, 2021.
Background: Despite recommendations for standardized preoperative waiting of at least 3, 5, and 7 days for ticagrelor, clopidogrel, and prasugrel, respectively, there is still substantial interinstitutional variation in preoperative discontinuation of dual antiplatelet therapy in patients needing coronary artery bypass grafting (CABG).
Methods: In 299 patients undergoing CABG with or without valve intervention less than 7 days after last P2Y receptor inhibition, this study evaluated calculated red blood cell loss and Bleeding Academic Research Consortium type 4 (BARC-4) bleeding.
Results: A total of 83% of patients underwent CABG less than 48 hours after last drug intake.