Psychological Coping Factors Associated With Breast Cancer-Related Fatigue: A Systematic Review of Recent Evidence for Stages 0 to III.

Cancer-related fatigue (CRF) is a common, distressing, and difficult to treat symptom for both breast cancer patients and survivors. This review investigates psychological coping factors associated with breast CRF (BCRF) for women who are stage 0 to III breast cancer patients or survivors. A focus was made on active factors that can be practically targeted in a fatigue focused intervention aimed at providing immediate results.

Adipocytes induce distinct gene expression profiles in mammary tumor cells and enhance inflammatory signaling in invasive breast cancer cells.

Obesity is a known risk factor for breast cancer. Since obesity rates are constantly rising worldwide, understanding the molecular details of the interaction between adipose tissue and breast tumors becomes an urgent task. To investigate potential molecular changes in breast cancer cells induced by co-existing adipocytes, we used a co-culture system of different breast cancer cell lines (MCF-7 and T47D: ER/PR/HER2 and MDA-MB-231: ER/PR/HER2) and murine 3T3-L1 adipocytes.

Differences in serum zinc levels in acutely ill and remitted adolescents and young adults with bulimia nervosa in comparison with healthy controls - a cross-sectional pilot study.

Background: Research has implicated that changes in zinc (Zn) metabolism may be associated with the biological underpinnings of eating disorders, in particular anorexia nervosa. However, to date research on the role of Zn in patients with bulimia nervosa (BN) is scarce.

Objective: We aimed to explore serum Zn concentrations in young patients with BN, with a focus on the stage of the disorder, comparing acutely ill and recovered patients with BN with healthy controls.

Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency.

Context And Aims: Functional leptin deficiency is characterized by high levels of circulating immunoreactive leptin (irLep), but a reduced bioactivity of the hormone due to defective receptor binding. As a result of the fact that affected patients can be successfully treated with metreleptin, it was aimed to develop and validate a diagnostic tool to detect functional leptin deficiency.

Methods: An immunoassay capable of recognizing the functionally relevant receptor-binding complex with leptin was developed (bioLep).

The soluble leptin receptor.

The adipokine leptin realizes signal transduction via four different leptin receptor (OB-R) isoforms. The amount of functionally active OB-R, however, is affected by constitutive shedding of the extracellular domain. The product of the cleavage process, the so-called soluble leptin receptor (sOB-R), is the main binding protein for leptin in human blood and modulates its bioavailability.

Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report.

A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (-3.

Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa.

Objective: To study adipokines as a potential link between obesity and male subfertility.

Design: Cross-sectional study of subjects stratified into subgroups according to body mass index (BMI): normal-weight (18.50-24.

Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.

Background: The adipokine leptin realizes signal transduction via four different membrane-anchored leptin receptor (Ob-R) isoforms in humans. However, the amount of functionally active Ob-R is affected by constitutive shedding of the extracellular domain via a so far unknown mechanism. The product of the cleavage process the so-called soluble leptin receptor (sOb-R) is the main binding protein for leptin in human blood and modulates its bioavailability.

Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth hormone activity in mice.

Serum IGF-I is a well-established pharmacodynamic marker of GH administration in humans and has been used for this purpose in animal studies. However, its general suitability in wild-type laboratory mice has not been demonstrated. Here we show that treatment with recombinant human GH (rhGH) in four different strains of laboratory mice increases body weight, lean body mass, and liver weight but does not increase hepatic expression and release of IGF-I.

New predictors of the metabolic syndrome in children--role of adipocytokines.

There is ample discussion of the relevance of the metabolic syndrome, the definition criteria, and predictive power. Nevertheless, along with the increasing prevalence of childhood obesity, the prevalence of the metabolic syndrome in obese children is reported at 30%, irrespective of the definition applied. Because children are otherwise relatively free of co-morbidities, they constitute an interesting population in which to study the sequence of events of obesity-related pathology.