Publications by authors named "Michael S Stosich"
Facial reconstruction by biosurgery: cell transplantation versus cell homing.
Tissue Eng Part B Rev
April 2010
Article Synopsis
- The face is crucial for individual identity, and disfigurements due to various causes create a strong patient desire for both functional and aesthetic restoration.
- Current reconstruction methods often fall short of expectations, and there is a need to integrate advancements from areas like stem cell biology and tissue engineering into facial reconstruction.
- The proposed concept of "biosurgery" aims to utilize innovative strategies like cell homing and targeted delivery to enhance regeneration and minimize surgical trauma while ensuring scientifically-based products for effective results.
Tissue engineering offers the possibility for soft tissue reconstruction and augmentation without autologous grafting or conventional synthetic materials. Two critical challenges have been addressed in a number of recent studies: a biology challenge of angiogenesis and an engineering challenge of shape maintenance. These two challenges are inter-related and are effectively addressed by integrated bioengineering strategies.
View Article and Find Full Text PDFVascularization is critical to the survival of engineered tissues. This study combined biophysical and bioactive approaches to induce neovascularization in vivo. Further, we tested the effects of engineered vascularization on adipose tissue grafts.
View Article and Find Full Text PDFBackground: Despite certain levels of clinical efficacy, current autografts and synthetic materials for soft-tissue reconstruction and/or augmentation suffer from donor-site morbidity, rupture, dislocation, and volume reduction. Human adult stem cells can self-replicate and differentiate into adipogenic cells in response to appropriate signaling cues. This study investigated the shape and dimension maintenance of engineered adipose tissue from adult human mesenchymal stem cells.
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