Publications by authors named "Michael S Hoffman"

Spinal injury disrupts connections between the brain and spinal cord, causing life-long paralysis. Most spinal injuries are incomplete, leaving spared neural pathways to motor neurons that initiate and coordinate movement. One therapeutic strategy to induce functional motor recovery is to harness plasticity in these spared neural pathways.

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Article Synopsis
  • Plasticity in the nervous system is key for controlling breathing, particularly through long-term facilitation of phrenic motor output (pLTF) after experiencing short episodes of low oxygen levels (acute intermittent hypoxia or AIH).
  • This process involves spinal plasticity that enhances respiratory output and depends on the production of specific proteins and activation of certain receptors in phrenic motor neurons.
  • Researchers are investigating how repetitive AIH could be used to improve breathing function in individuals with conditions like cervical spinal injuries, potentially restoring respiratory capabilities in those with partial spinal cord damage.
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Article Synopsis
  • Neural plasticity, including in breathing control, is important but not fully understood, particularly in how it relates to respiratory mechanisms.
  • Recent research has advanced our knowledge of phrenic long-term facilitation (pLTF), a lasting increase in diaphragm activity following acute intermittent hypoxia (AIH).
  • The study introduces two pathways, "Q" and "S," linked to different receptor proteins that contribute to this process and highlight their complex interactions in response to physiological changes or diseases.
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Can people "see" previously unnoticed properties in objects that they visualize, or are they locked into the organization of the pattern that was encoded during perception? To answer this question, we first asked a group to describe letters of the alphabet and found that some properties (such as the presence of a diagonal line) are often mentioned, whereas others (such as symmetry) are rarely if ever mentioned. Then we showed not only that other participants could correctly detect both kinds of properties in visualized letters, but also that the relative differences in the ease of detecting these two types of properties are highly similar in perception (when the letters are actually visible) and imagery (when the letters are merely visualized). These findings provide support for the view that images can be reinterpreted in ways much like what occurs during perception and speak to the wider issue of the long-standing debate about the format of mental images.

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