Publications by authors named "Michael Roll"
Article Synopsis
- Age-related macular degeneration (AMD) and related macular dystrophies (MDs) primarily impact the retinal pigment epithelium (RPE) with drusen deposits being a key feature in the progression of these diseases.
- The research indicates that reduced activity of matrix metalloproteinase 2 (MMP2) in RPE contributes to drusen formation by causing sterile inflammation and disrupting lipid balance, interacting with specific receptors and molecules.
- Therapeutic approaches including MMP2 supplementation and inhibiting RAGE and sPLA2-IIA have shown promise in reducing drusen accumulation in patient-derived RPE cells, highlighting a potential treatment pathway for AMD/MDs.
Mutations in CLN3 lead to photoreceptor cell loss in CLN3 disease, a lysosomal storage disorder characterized by childhood-onset vision loss, neurological impairment, and premature death. However, how CLN3 mutations cause photoreceptor cell death is not known. Here, we show that CLN3 is required for phagocytosis of photoreceptor outer segment (POS) by retinal pigment epithelium (RPE) cells, a cellular process essential for photoreceptor survival.
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