Prognostic significance of immunohistochemical expression of VEGFR2 and iNOS in spinal chordoma.

Purpose: To clarify whether vascular endothelial growth factor receptor 2 (VEGFR2) and inducible nitric oxide synthase (iNOS) are involved in the angiogenesis and recurrence of spinal chordoma tissues and influence the overall survival.

Methods: All patients affected by a spinal chordoma surgically treated between 1986 and 2007 were reviewed. We examined the expression of VEGFR2 and iNOS with immunohistochemistry using a tissue microarray containing 120 chordoma samples.

Expression of PDGFR-α, EGFR and c-MET in spinal chordoma: a series of 52 patients.

Aim: To investigate the expression of platelet-derived growth factor (PDGF) receptor-A (PDGFRα), epidermal growth factor receptor (EGFR) and c-Met in spinal chordoma. To the authors' knowledge, little is known regarding the prognostic significance of receptor tyrosine kinase in spinal chordoma.

Materials And Methods: Using immunohistochemical techniques, the authors investigated PDGFR-α, EGFR and c-MET expression in 52 primary and 104 recurrent lesions, and compared these data with clinicopathological parameters.

Endoscopic endonasal transsphenoidal approach to sellar lesions: a detailed account of our mononostril technique.

Objective The endonasal endoscopic approach is currently under investigation for perisellar tumor surgery. A higher resection rate is to be expected and nasal complications should be minimized. Here, the authors report their technique of transnasal endoscopic neurosurgery after 218 procedures.

Ultrasonic aspiration in neuroendoscopy: first results with a new tool.

Neuroendoscopic techniques are often considered inapplicable to lesion resection because most lesions are too large for effective endoscopic resection in an appropriate time frame. To evaluate the potential of ultrasonic aspiration in neuroendoscopic procedures, the authors developed a new handpiece for endoscopic application. The instrument was subsequently tested in 10 cadaveric pig brains and applied in 5 clinical cases.

Waterjet dissection of the vestibulocochlear nerve: an experimental study.

Object: Waterjet dissection has been shown to protect intracerebral vessels, but no experience exists in applying this modality to the cranial nerves. To evaluate its potential, the authors examined waterjet dissection of the vestibulocochlear nerve in rats.

Methods: Lateral suboccipital craniectomy and microsurgical preparation of the vestibulocochlear nerve were performed in 42 rats.

Prognosis of gliomas in the 1970s and today.

The benefit of the current strategy for diagnosis (magnetic resonance, [MR] imaging) and treatment (surgery, chemotherapy, radiotherapy) of gliomas, in contrast to the standard treatment in use before MR imaging and the microsurgical era, has not yet been determined. A retrospective statistical analysis was performed for all patients with glioma who underwent surgery at a single institution between 1965 and 1974 (Group I, 88 patients) or 1986 and 1995 (Group II, 249 patients). There were no major differences in symptomatology, tumor localization, and number of surgical procedures.

Waterjet dissection versus ultrasonic aspiration in epilepsy surgery.

Objective: Waterjet dissection is currently under close investigation in neurosurgery. Experimentally, precise brain parenchyma dissection with vessel preservation has been demonstrated. Clinically, the safety of the instrument has already been proved.

Neuronavigation and complication rate in epilepsy surgery.

The role of neuronavigation for complications in temporal lobe epilepsy surgery was evaluated. Thirty-seven patients operated on with neuronavigation (group N: 38 operations; mean age 33.9 years; etiology: cryptogenetic 31, symptomatic 7; lateralization: 22 right, 16 left) and 22 patients operated on without neuronavigation (group NN: 23 operations; mean age 29.

Comparison of waterjet dissection and ultrasonic aspiration: an in vivo study in the rabbit brain.

Object: The waterjet method of dissection has been shown to enable the precise dissection of the parenchyma vessels while preserving blood in cadaveric pig brains. The waterjet device has also been applied clinically to treat various diseases and disorders without complications. Evidence still remains to be gathered as to how the instrument performs in reducing surgical trauma, intraoperative blood loss, and postsurgical brain edema.

Waterjet dissection in the brain: review of the experimental and clinical data with special reference to meningioma surgery.

Waterjet dissection enables precise parenchymal dissection under preservation of vessels and reduction of intraoperative blood loss in general surgery. The present study reports our experimental and clinical results with this device in neurosurgery. Our experimental studies in the porcine cadaver brain show that the device allows very accurate, precise, and reliable dissection of the brain.

Water jet dissection in neurosurgery: experimental results in the porcine cadaveric brain.

Objective: Water jet dissection is currently under investigation as a new tool for use in neurosurgical procedures. The safety of this instrument has already been demonstrated. However, precise data demonstrating highly accurate tissue dissection in the brain in combination with vessel preservation are still missing.

Waterjet dissection in neurosurgical procedures: clinical results in 35 patients.

Object: Waterjet dissection represents a new minimally traumatic surgical method for dissection that can be used in various parenchymal organs, in which it allows highly precise parenchymal dissection while preserving blood vessels, resulting in reduced intraoperative blood loss. This study was performed to investigate the clinical application of this new technique in neurosurgical procedures, such as brain tumor resection and epilepsy surgery.

Methods: Thirty-four patients with gliomas (Grades II-IV), cerebral metastases, temporal lobe epilepsy, or cerebellar hemangioblastomas, and one patient with internal carotid artery (ICA) stenosis were treated surgically with the aid of the waterjet.