Publications by authors named "Michael Riedy"
J Biomol Struct Dyn
May 2018
Article Synopsis
- Genetic screens in yeast identified Hsp40 (Ydj1p) J-domain mutants that struggle to eliminate the [URE3] prion by disrupting Hsp70 interactions.
- Biochemical studies on these mutants haven't clarified specific changes in Hsp40-Hsp70 interactions, prompting further investigation through 20 ns molecular dynamics simulations.
- Results highlighted that while the mutants had different mechanisms for interacting with Hsp70, a key structural change occurred in the HPD motif of the J-domain, with residues Y26 and F45 confirmed as critical for the function of Ydj1p.
