Publications by authors named "Michael R Hussey"
Introduction: Traffic-related air pollution (TRAP), a common exposure, potentially impacts pregnancy through altered placental function. We investigated associations between prenatal TRAP exposure and placental gene expression.
Methods: Whole transcriptome sequencing was performed on placental samples from CANDLE (Memphis, TN) (n = 776) and GAPPS (Seattle and Yakima, WA) (n = 205), cohorts of the ECHO-PATHWAYS Consortium.
Placental cadmium, placental genetic variations, and birth size.
J Matern Fetal Neonatal Med
December 2022
Background: Maternal cadmium (Cd) burden has been associated with offspring birth size measures, yet associations of placental Cd with birth size are less clear. Further, the role of genetics in these associations has not been examined. We investigated associations of placental Cd with birth size and placental genotypes.
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- Exposure to heavy metals like cadmium can negatively impact infant birth weight and other developmental outcomes, potentially through placental dysfunction.
- The study analyzed the relationship between long non-coding RNAs (lncRNAs) in the placenta and cadmium levels, using data from RNA sequencing to assess their impact on infant birth weight.
- Findings indicated that specific lncRNAs were associated with both cadmium exposure and variations in birth weight, suggesting that lncRNA expression changes in the placenta could contribute to the reproductive toxicity of cadmium.
Mispositioned nuclei are a hallmark of skeletal muscle disease. Many of the genes that are linked to Emery-Dreifuss muscular dystrophy (EDMD) encode proteins that are critical for nuclear movement in various cells, suggesting that disruptions in nuclear movement and position may contribute to disease progression. However, how these genes are coordinated to move nuclei is not known.
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