Publications by authors named "Michael R Freund"
Article Synopsis
- The study assessed the impact of neoadjuvant radiation therapy on patients with stage II and III mucinous rectal carcinoma, utilizing data from the National Cancer Database from 2004 to 2019.
- Results showed that while overall survival rates were similar between patients who received radiation (81.9 months) and those who did not (77.3 months), radiation therapy led to lower rates of advanced pathologic disease and fewer examined lymph nodes.
- Despite these differences, the study found no significant impact on short-term mortality, readmission, or length of hospital stay related to the use of neoadjuvant radiation therapy.
Background: This study aimed to determine predictors of overall survival (OS) after surgical treatment of stage I-III appendiceal adenocarcinoma and compare the outcomes of partial colectomy and hemicolectomy.
Methods: A retrospective analysis of the U.S.
Background: Rectal cancer patients with microsatellite instability (MSI-H) are candidates for immunotherapy. However, there is little evidence on its effect on overall survival (OS).
Methods: Retrospective analysis of stage II-IV rectal adenocarcinoma patients in the National Cancer Database (NCDB) between 2010 and 2019.
Article Synopsis
- This systematic review investigated various medications for preventing and treating pouchitis after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA).
- The analysis included 15 randomized trials, revealing that probiotics significantly reduced the odds of pouchitis and had a similar side effect profile as placebo.
- Antibiotics, specifically ciprofloxacin and metronidazole, were found to be effective for treating active pouchitis, while other treatments like rifaximin and adalimumab showed no effectiveness.
Background: Despite the pivotal role of magnetic resonance imaging (MRI) in rectal cancer staging and evaluation, the reliability of restaging MRI after neoadjuvant therapy is still debatable. This study aimed to assess the accuracy of restaging MRI by comparing post-neoadjuvant MRI findings with those of the final pathology.
Methods: This study was a retrospective review of the medical records of adult rectal cancer patients who had restaging MRI following neoadjuvant therapy and prior to rectal cancer resection in a NAPRC-certified rectal cancer centre between 2016 and 2021.
Objective: To assess long-term outcomes of patients with perforated diverticulitis treated with resection or laparoscopic lavage (LL).
Background: Surgical treatment of perforated diverticulitis has changed in the last few decades. LL and increasing evidence that primary anastomosis (PRA) is feasible in certain patients have broadened surgical options.
Purpose: To assess whether full bowel preparation affects 30-day surgical outcomes in laparoscopic right colectomy for colon cancer.
Methods: A retrospective chart review of all elective laparoscopic right colectomies performed for colonic adenocarcinoma between Jan 2011 and Dec 2021. The cohort was divided into two groups-no bowel preparation (NP) group and patients who received full bowel preparation (FP), including oral and mechanical cathartic bowel preparation.
Aim: We aimed to determine whether ulcerative colitis patients with preoperative negative computed tomography or magnetic resonance enterography (CTE/MRE) were less likely to develop Crohn's disease-like pouch complications (CDLPC) and establish risk factors and predictors for developing CDLPC.
Methods: This was a single centre retrospective analysis of patients with ulcerative colitis (UC) and inflammatory bowel disease unclassified (IBDU) who underwent total proctocolectomy with ileal J-pouch between January 2010 and December 2020. The study group comprised patients with negative preoperative CTE/MRE and the control group included patients operated without preoperative CTE/MRE.
Purpose: There is an ongoing debate regarding the extent of resection for splenic flexure tumors (SFT). The purpose of this study was to compare segmental and extended resections in terms of overall survival (OS) and pathologic outcomes.
Methods: Retrospective analysis of all patients surgically treated for SFT in the National Cancer Database (NCDB) for the period 2010-2019.
Aim: This study aimed to assess success, recurrence, and overall complication rates among different surgical procedures for stomal prolapse.
Methods: This study was a PRISMA-compliant systematic review. PubMed, Scopus, and Google Scholar were searched until March 2022.
Article Synopsis
- Transanal local excision is gaining popularity for treating early-stage rectal cancer, but the factors influencing positive resection margins have not been extensively studied.
- A retrospective analysis of data from nonmetastatic T1 rectal adenocarcinoma patients highlighted a 7.4% rate of positive surgical margins, with predictors including older age, higher comorbidity, and specific cancer types.
- The study found that patients with positive margins had significantly shorter overall survival compared to those with negative margins, indicating a need for careful assessment of surgery outcomes.
Background: Distal tumor spread (DTS) is an adverse prognostic factor in rectal cancer correlating with advanced stage disease. We aimed to assess prevalence and location of distal tumor spread and impact of neoadjuvant chemoradiotherapy (NACRT) in patients who underwent proctectomy for rectal cancer.
Methods: The pathology database at our institution was queried for all patients who underwent proctectomy with curative intent for rectal cancer from 1/2008 to 12/2016.
Background And Purpose: Rectal sarcomas (RS) are rare malignant tumors with a very poor prognosis. This study aimed to assess the characteristics, treatment, and outcomes of RS in the United States.
Methods: This study was a retrospective analysis of the National Cancer Database (NCDB) from 2004 to 2019 of patients with a diagnosis of RS.
Background: We aimed to assess characteristics, treatment, and outcomes of rectal melanoma (RM).
Methods: This retrospective cohort study looked at patients with RM from National Cancer Database (2004-2019) analyzed characteristics and outcomes of the entire cohort and across three time periods (2004-2009; 2010-2014; 2015-2019). Main outcome measures were change in treatment and survival trends across time periods and overall survival (OS).
Background: Total mesorectal excision is the standard surgical procedure for rectal cancer treatment. Several studies have shown a close correlation between the prognosis of patients with rectal cancer and the completeness of the mesorectal specimen.
Objective: To assess the correlation between macroscopic assessment of mesorectal excision and long-term oncological outcomes.
Importance: Rectal cancer management has significantly evolved over the last 2 decades.
Objective: This study aimed to evaluate trends in the characteristics, treatment, and outcomes of rectal adenocarcinoma across 16 years.
Design, Setting, And Participants: This retrospective, observational case series study used data from the National Cancer Database (NCDB) to evaluate patients diagnosed with rectal adenocarcinoma from 2004 through 2019.
Background: Unplanned 30-day readmission is common after major surgery, including rectal cancer surgery. The present study aimed to assess the rate and predictors of unplanned 30-day readmission after proctectomy for rectal cancer.
Methods: This was a retrospective case-control study using data from the National Cancer Database.
Background: T4 rectal cancer is a challenging condition owing to the highly invasive nature of the tumour that may compromise R0 resection. The present study aimed to assess the outcomes of laparoscopic versus robotic-assisted resection of non-metastatic T4 rectal adenocarcinoma.
Methods: This was a retrospective propensity score-matched analysis using the National Cancer Database between 2010 and 2019.
Aim: Complex perineal fistulas (CPFs) are among the most challenging problems in colorectal practice. Various procedures have been used to treat CPFs, with none being a panacea. Our study aimed to assess the overall success and complication rates after gracilis muscle interposition in patients with CPF.
View Article and Find Full Text PDFBackground: Recurrence of postoperative Crohn's disease neccesitating repeat ileocolic resection is a common problem. The aim of this meta-analysis was to present the collective evidence on the surgical outcomes of this procedure.
Methods: PubMed, Scopus, and Google Scholar were searched for eligible studies that reported the surgical outcomes of redo ileocolic resection for Crohn's disease.
Background: Clinical assessment of T and N stages in rectal cancer is important to guide decision-making. The present study aimed to assess the accuracy of the clinical T and N staging of rectal cancer compared to the pathological staging and their overall agreement in a large cohort of patients.
Methods: This retrospective study used data from the National Cancer Database (NCDB) between 2004 and 2017.
Introduction: Total neoadjuvant therapy (TNT) is a new therapeutic strategy in patients with rectal cancer. We examined the role of TNT, in addition to other pre-operative factors, as a predictor for pathologic complete response (pCR).
Methods: A retrospective analysis of all rectal cancer patients who underwent surgery between 2016 and 2021 was conducted.
Background: Gastrointestinal stromal tumors (GISTs) account for <1% of gastrointestinal cancers. The present study aimed to assess the outcomes of local and radical excision of non-metastatic rectal GISTs.
Methods: This study was a retrospective cohort analysis of patients with non-metastatic rectal GISTs in the NCDB.
Background: Repeat ileocolic resection of Crohn's disease (CD) is a challenging procedure that can be followed by a high rate of complications. The present study aimed to identify the factors associated with complications and conversion to open surgery in patients undergoing repeat ileocolic resection for CD.
Methods: This was a retrospective review of an IRB-approved prospective database of CD patients who underwent elective repeat ileocolic resection between 2011 and 2021.