Publications by authors named "Michael Quiquempoix"
Background: Caffeine is a well-known psychostimulant reputed to alleviate the deleterious effects of sleep deprivation. Nevertheless, caffeine can alter sleep duration and quality, particularly during recovery sleep. We evaluated the effects of acute caffeine intake on the duration and quality of recovery sleep following total sleep deprivation (TSD), taking into account daily caffeine consumption.
View Article and Find Full Text PDFIntroduction: Exposure to moderate levels of simulated hypoxia has subtle cognitive effects relative to ground level, in healthy individuals. However, there are few data on the cognitive consequences of the combination of hypoxia and partial sleep deprivation, which is a classic military or civilian operational context. In this study, we tested the hypothesis that exposure to moderate hypoxia while sleep-restricted impairs several domains of cognition, and we also assessed physiological parameters and salivary concentrations of cortisol and alpha-amylase.
View Article and Find Full Text PDFAircraft pilots face a high mental workload (MW) under environmental constraints induced by high altitude and sometimes sleep restriction (SR). Our aim was to assess the combined effects of hypoxia and sleep restriction on cognitive and physiological responses to different MW levels using the Multi-Attribute Test Battery (MATB)-II with an additional auditory Oddball-like task. Seventeen healthy subjects were subjected in random order to three 12-min periods of increased MW level (low, medium, and high): sleep restriction (SR, <3 h of total sleep time (TST)) vs.
View Article and Find Full Text PDFMulti-Attribute Task Battery (MATB) is a computerized flight simulator for aviation-related tasks, suitable for non-pilots and available in many versions, including open source. MATB requires the individual or simultaneous execution of 4 sub-tasks: system monitoring (SYSMON), tracking (TRACK), communications (COMM), and resource management (RESMAN). Fully customizable, the design of test duration, number of sub-tasks used, event rates, response times and overlap, create different levels of mental load.
View Article and Find Full Text PDFArticle Synopsis
- Caffeine acts as a psychostimulant that can alleviate the negative effects of sleep deprivation, and this study aimed to examine its impact on cognitive performance and brain activity during complete sleep loss, while considering each individual's caffeine habits.* -
- The study included 37 participants in a double-blind experiment where they underwent total sleep deprivation with either caffeine or placebo; their attention was measured using a test every six hours, alongside EEG monitoring to analyze brain activity.* -
- Results showed that caffeine improved reaction times compared to the placebo during sleep deprivation; however, individuals with high caffeine consumption exhibited poorer attentional performance, indicating that habitual high caffeine intake may worsen the ability to cope with sleep loss.*
Article Synopsis
- Trauma-related nightmares (TRNs) significantly affect the sleep quality and treatment outcomes of PTSD patients, making it important to study them in realistic home environments rather than sleep labs.
- The study utilized two ambulatory devices to collect objective sleep data from 60 veterans and active-duty service members, correlating this data with their subjective complaints about sleep and TRNs over five nights.
- Findings showed a connection between TRNs and sleep stages, revealing that most awakenings from TRNs occurred during NREM sleep, alongside differences in electrodermal activity (EDA) before TRNs, suggesting EDA may serve as a potential marker for these nightmares.
Introduction: It is widely admitted that both total sleep deprivation (TSD) and extended task engagement (Time-On-Task, TOT) induce a cognitive fatigue state in healthy subjects. Even if EEG theta activity and adenosine both increase with cognitive fatigue, it remains unclear if these modifications are common mechanisms for both sustained attention and executive processes.
Methods: We performed a double-blind counter-balanced (placebo (PCBO) and caffeine (CAF) - 2×2.
Several genetic polymorphisms differentiate between healthy individuals who are more cognitively vulnerable or resistant during total sleep deprivation (TSD). Common metrics of cognitive functioning for classifying vulnerable and resilient individuals include the Psychomotor Vigilance Test (PVT), Go/noGo executive inhibition task, and subjective daytime sleepiness. We evaluated the influence of 14 single-nucleotide polymorphisms (SNPs) on cognitive responses during total sleep deprivation (continuous wakefulness for 38 h) in 47 healthy subjects (age 37.
View Article and Find Full Text PDFStudy Objectives: Total sleep deprivation is known to have significant detrimental effects on cognitive and socio-emotional functioning. Nonetheless, the mechanisms by which total sleep loss disturbs decision-making in social contexts are poorly understood. Here, we investigated the impact of total sleep deprivation on approach/avoidance decisions when faced with threatening individuals, as well as the potential moderating role of sleep-related mood changes.
View Article and Find Full Text PDFArticle Synopsis
- Researchers used piezoelectric sensors to monitor sleep patterns in rats, comparing its effectiveness to traditional electroencephalogram (EEG) methods over 7 days.
- Both methods showed similar results regarding total sleep time, with longer sleep detected under certain lighting conditions, and correlated closely with each other.
- The piezoelectric system demonstrated a 90% accuracy in distinguishing between non-rapid eye movement and rapid eye movement sleep, making it a promising non-invasive tool for studying sleep and its effects on health.
Article Synopsis
- The study explored how specific genetic variations (SNPs) affect the impact of caffeine on attention and performance during sleep deprivation in 37 participants.
- It found that carriers of certain SNPs (TNF-α and COMT) were more sensitive to caffeine's effects, but this did not improve their performance despite increased degradation from sleep loss.
- Additionally, genetic factors influenced EEG activity related to sleep deprivation, highlighting that caffeine can partially mitigate neurobehavioral impairments linked to sleep loss.
Initial anatomical and physiological studies suggested that sensory information relayed from the periphery by the thalamus is serially processed in primary sensory cortical areas. It is thought to propagate from layer 4 (L4) up to L2/3 and down to L5, which constitutes the main output of the cortex. However, more recent experiments point toward the existence of a direct processing of thalamic input by L5 neurons.
View Article and Find Full Text PDF