Extended time-of-flight measurements down to 100 keV at the AMANDE facility with a stilbene scintillator.

The time-of-flight (ToF) method with scintillators is routinely used for determining neutron energy. However, a technical difficulty related to the loss of scintillator efficiency below 1 MeV makes this technique difficult to implement for the energy decade [100 keV-1 MeV]. New crystal production techniques provide stilbene scintillators efficient in this low neutron energy region, making it possible to extend the ToF technique below 1 MeV.

Modulation of CYP3a expression and activity in mice models of type 1 and type 2 diabetes.

CYP3A4, the most abundant cytochrome P450 enzyme in the human liver and small intestine, is responsible for the metabolism of about 50% of all marketed drugs. Numerous pathophysiological factors, such as diabetes and obesity, were shown to affect CYP3A activity. Evidences suggest that drug disposition is altered in type 1 (T1D) and type 2 diabetes (T2D).