Steerable intravitreal inserts for drug delivery: in vitro and ex vivo mobility experiments.

The progress of wet age-related macular degeneration can now be controlled by intravitreal drug injection. This approach requires repeated injections, which could be avoided by delivering the drug to the retina. Intraocular implants are a promising solution for drug delivery near the retina.

Artificial vitreous humor for in vitro experiments.

In this paper we present a protocol to create artificial vitreous humor phantom tissue to be used as a test bed for in vitro experiments. The artificial vitreous consists of water, agar, and hyaluronic acid. Unlike existing vitreous replacement substances, this dummy tissue exhibits viscoelastic characteristics of in vivo natural vitreous humor.