The effects of prenatal cocaine exposure on reversal learning using a simple visual discrimination task in rhesus monkeys.

The purpose of this research was to determine if adult animals that were exposed to cocaine prenatally would be able to adapt to changes in the rules of reinforcement for a simple discrimination task. Treatment groups included 0.0, 1.

Acute Effects of Dexfenfluramine (d-FEN) and Methylenedioxymethamphetamine (MDMA) before and after Short-Course, High-Dose Treatment.

The acute behavioral effects of methylenedioxymethamphetamine (MDMA) and dexfenfluramine (d-FEN) were assessed in six rhesus monkeys using performance in the National Center for Toxicological Research (NCTR) Operant Test Battery (OTB); three additional animals served as controls for neurochemical endpoints. The OTB consists of five food-reinforced tasks designed to model aspects of learning, short-term memory and attention, time estimation, motivation, and color and position discrimination. Shortly after the acute effects of each drug were determined, three of the monkeys received a short-course, high-dose exposure (2×/day × 4 days, intramuscular (i.

The Effects of Cocaine on Nonhuman Primate Brain Function Are Age Dependent.

The effects of acute intravenous (i.v.) cocaine (COC) on several complex brain functions were studied in rhesus monkeys at 1.