Publications by authors named "Michael P Fischer"
Article Synopsis
- * A CDC report analyzed 57 hospitalized monkeypox patients from August to October 2022, revealing that 82% had HIV, most were male (95%), and 68% were non-Hispanic Black; 30% needed ICU care, and 21% died due to severe symptoms.
- * Health care providers are advised to test sexually active monkeypox patients for HIV and consider aggressive treatment for those who are severely immunocompromised
Article Synopsis
- NKCC1 null mice exhibit hypotension primarily due to a lack of NKCC1-mediated vasoconstriction, raising questions about their kidney function in sodium and water balance.
- The study investigates whether these mice have issues regulating NaCl and water that contribute to their low blood pressure and examines potential hormonal and transporter expression changes in the kidneys.
- Results show NKCC1 null mice have lower blood pressure, altered hormonal levels (like higher renin and lower ANP), and reduced ability to excrete free water, leading to issues like hypochloremia, despite increased expression of some sodium transporters.
ANG II reduces net acid secretion in rat outer medullary collecting duct.
Am J Physiol Renal Physiol
November 2003
In rat outer medullary collecting duct (OMCD), the mechanism(s) and regulation of H+ secretion are not understood fully. The effect of changes in acid-base balance and the renin-angiotensin system on net H+ secretion was explored. Rats received NaCl, NaHCO3, NH4Cl, or nothing in their drinking water for 7 days.
View Article and Find Full Text PDFIn rat kidney, the "secretory" isoform of the Na-K-Cl cotransporter, NKCC1 (BSC-2), localizes to the basolateral membrane of the alpha intercalated cell, the acid secreting cell of the outer medullary collecting duct (OMCD). This laboratory has reported that NKCC1 mediates Cl(-) uptake across the basolateral membrane in series with Cl(-) secretion across the apical membrane in rat OMCD. NKCC1 transports NH(4)(+), K(+), and Na(+) as well as Cl(-); therefore, a role for the cotransporter in the process of HCl, NH(4)Cl, KCl, and NaCl secretion has been suggested.
View Article and Find Full Text PDFIn rat inner medullary collecting duct, NH uptake by the Na,K-ATPase is increased during hypokalemia.
Am J Physiol Renal Physiol
January 2002
In rat terminal inner medullary collecting duct (tIMCD), the Na,K-ATPase mediates NH uptake, which increases secretion of net H(+) equivalents. K(+) and NH compete for a common binding site on the Na,K-ATPase. Therefore, NH uptake should increase during hypokalemia because interstitial K(+) concentration is reduced.
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