Publications by authors named "Michael P Archambault"
Article Synopsis
- Mesenchymal stem cells (MSCs) have low immunogenicity and immunomodulatory abilities, suggesting safe transplantation in immunocompetent recipients without immunosuppression.
- In an experiment with baboons, three groups received either no treatment, MSCs from the same donor, or MSCs from different donors, with muscle biopsies showing MSC persistence in 50% of animals after treatment.
- The study found that while recipient baboons developed alloantibodies against donor cells, their overall T-cell response remained unaffected, indicating that repeated high doses of allogeneic MSCs can modulate immune responses, potentially enhancing MSC survival.
Background: Mesenchymal stem cells from adult bone marrow are multipotent cells capable of forming bone, cartilage, and other connective tissues. In a previous study, we demonstrated that autologous mesenchymal stem cells could repair a critical-sized bone defect in the dog. The objective of this study was to determine whether the use of allogeneic mesenchymal stem cells could heal a critical-sized bone defect in the femoral diaphysis in dogs without the use of immunosuppressive therapy.
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