Intraocular Injection of HyStem Hydrogel Is Tolerated Well in the Rabbit Eye.

To determine the long-term biocompatibility of HyStem hydrogel in the rabbit eye for use as a carrier for cell or drug delivery into the ocular space. HyStem hydrogel formulation solidifies ∼20 min after reconstitution, thus can potentially form a solid deposit after injection . To study the ocular disposition of fluorescein-labeled HyStem, we delivered 50 μL/eye over 1 min into the vitreous space of the rabbit.