Murine Skin Model for Biofilm.

, the causative agent of Lyme disease, has been recently shown to form biofilm structures in vitro and . Biofilms are tightly clustered microbes characterized as resistant aggregations that allow bacteria to withstand harsh environmental conditions, including the administration of antibiotics. Novel antibiotic combinations have recently been identified for , however, due to prohibiting costs, those agents have not been tested in an environment that can mimic the host tissue.

The Long-Term Persistence of Antigens and DNA in the Tissues of a Patient with Lyme Disease.

Whether the causative agent of Lyme disease, can persist for long periods in the human body has been a controversial question. The objective of this study was to see if we could find in a Lyme disease patient after a long clinical course and after long-term antibiotic treatment. Therefore, we investigated the potential presence of antigens and DNA in human autopsy tissues from a well-documented serum-, PCR-, and culture-positive Lyme disease patient, a 53-year-old female from northern Westchester County in the lower Hudson Valley Region of New York State, who had received extensive antibiotic treatments during extensive antibiotic treatments over the course of her 16-year-long illness.