p53 and MDM2 are involved in the regulation of osteocalcin gene expression.

Osteocalcin (OC) is a major noncollagenous bone matrix protein and an osteoblast marker whose expression is limited to mature osteoblasts during the late differentiation stage. In previous studies we have shown osteosarcomas to lose p53 function with a corresponding loss of osteocalcin gene expression. Introduction of wild type p53 resulted in re expression of the osteocalcin gene.

Barriers to screening for domestic violence.

Context: Domestic violence has an estimated 30% lifetime prevalence among women, yet physicians detect as few as 1 in 20 victims of abuse.

Objective: To identify factors associated with physicians' low screening rates for domestic violence and perceived barriers to screening.

Design: Cross-sectional postal survey.