Publications by authors named "Michael Nasert"
Objective: This study was conducted to compare therapeutically relevant properties of platelet-rich plasma (PRP), a commonly used autologous intra-articular treatment for osteoarthritis (OA), with those of a novel placental tissue particulate, PTP-001, which is in development as a regulated biologic treatment for knee OA.
Design: Quantitative immunoassays were performed to determine the content of key growth/regulatory biofactors in PTP-001, and in leukocyte-rich (LR)-PRP or leukocyte-poor (LP)-PRP. An anti-inflammatory bioassay was used to evaluate the effects of each treatment on pro-inflammatory cytokine (tumor necrosis factor (TNF)-α) production in a macrophage cell culture system.
Purpose: To assess the biomechanical performance of 2 different T-block modifications of bone-patella tendon-bone (BPTB) allografts.
Methods: The matched knee pairs from 10 human cadavers (mean age 49 years) were fashioned into 30 BPTB allografts and divided into 3 groups (10 each): group 1, standard patella tendon-tibial attachment; group 2, T-block tibial attachment with 10 mm of unattached bone proximal to the patella tendon insertion with 15 mm of tendon attached; group 3, T-block tibial attachment with 15 mm of unattached bone proximal to the patella tendon insertion and 10 mm of tendon attached. A biocomposite interference screw secured each graft into a 10-mm tunnel in 15 pcf polyurethane foam.
Purpose: To quantify the structural and material properties of 10-mm central sections of the quadriceps and patellar tendons in the setting of anterior cruciate ligament reconstruction using cadaveric grafts and biomechanical analysis.
Methods: The structural and mechanical properties of 11 bone-patellar tendon-bone (BPTB) and 12 quadriceps tendon-bone (QT) allografts were evaluated. Ten-millimeter-wide tendon grafts from both patellar and quadriceps tendons were harvested and subjected to biomechanical testing using the MTS servohydraulic test machine (MTS Systems, Eden Prairie, MN).