Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion.

Background: Ischemia and subsequent reperfusion (IR) may induce local and remote organ reperfusion injury. It may be propagated by xanthine oxidase (XO)-generated oxidant stress. We investigated whether pancreas IR directly and acutely induces renal dysfunction and if this outcome could be prevented by mannitol.