Publications by authors named "Michael Muratet"
Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo. Analysis of resting microglia identified 29 genes that distinguish microglia from other CNS cells and peripheral macrophages/monocytes.
View Article and Find Full Text PDFIntricate interplay between astrocytes and motor neurons in ALS.
Proc Natl Acad Sci U S A
February 2013
Article Synopsis
- ALS (Amyotrophic Lateral Sclerosis) involves the degeneration of motor neurons, with glial cells playing a significant role in disease progression.
- Research using the hSOD1(G93A) mouse model reveals that interactions between motor neurons and glial cells lead to notable changes in gene expression, proving that these cells influence each other significantly.
- The study finds a strong correlation between lab results (cell cultures) and gene expression in actual spinal tissues during ALS progression, highlighting specific genes and pathways like TGF-β that may contribute to motor neuron degeneration.
Th17 cells have critical roles in mucosal defense and are major contributors to inflammatory disease. Their differentiation requires the nuclear hormone receptor RORγt working with multiple other essential transcription factors (TFs). We have used an iterative systems approach, combining genome-wide TF occupancy, expression profiling of TF mutants, and expression time series to delineate the Th17 global transcriptional regulatory network.
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