Adaptive effects of 30-night wear of hyper-O(2) transmissible contact lenses on bacterial binding and corneal epithelium: a 1-year clinical trial.

Objective: To determine effects of lens type and oxygen transmissibility on human corneal epithelium during extended wear (EW).

Design: Prospective, randomized, double-masked, single-center, parallel treatment groups, 1-year clinical trial.

Participants: One hundred seventy-eight patients completed the study: (1) high-O(2) soft lens (6-night [N] EW) (n = 27); (2) hyper-O(2) soft lens (6N-EW, n = 33) or (30N-EW, n = 66); and (3) hyper-O(2) rigid gas-permeable lens (RGP) (30N-EW, n = 52).