Publications by authors named "Michael Mobaraki"
Article Synopsis
- Identified noncoding driver mutations in pancreatic ductal adenocarcinoma (PDAC) by mapping accessible chromatin regions and histone modifications in pancreatic cell lines and tissues, integrating this data with whole-genome mutations from 506 PDAC cases.
- *From 3,614 noncoding somatic mutations (NCSMs) found, 178 were shown to significantly affect gene activity, highlighting their potential role in cancer progression.
- *Further experiments pinpointed specific genes impacted by these mutations, with a focus on one gene (KLF9) that showed reduced expression due to interference from NCSMs, establishing it as a possible PDAC driver gene.
