Aeroacoustic source prediction using material surfaces bounding the flow.

This article presents an extension of Liepmann's characterization of an aeroacoustic source in terms of the motion of a bounding surface containing the source region. Rather than using an arbitrary surface, we express the problem in terms of bounding material surfaces, identified by Lagrangian Coherent Structures (LCS), which demarcate flow into regions with distinct dynamics. The sound generation of the flow is written in terms of the motion of these material surfaces using the Kirchhoff integral equation, so that the flow noise problem now appears like that of a deforming body.

Trilayered Hydrogel Scaffold for Vocal Fold Tissue Engineering.

The lamina propria within the vocal fold (VF) is a complex multilayered tissue that increases in stiffness from the superficial to deep layer, where this characteristic is crucial for VF sound production. Tissue-engineered scaffolds designed for VF repair must mimic the biophysical nature of the native vocal fold and promote cell viability, cell spreading, and vibration with air flow. In this study, we present a unique trilayered, partially degradable hydrogel scaffold that mimics the multilayered structure of the VF lamina propria.

A Tissue Engineered Construct for Laryngeal Regeneration: A Proof-of-Concept Device Design Study.

Objectives/hypothesis: Develop a patient-specific tissue engineered construct for laryngeal reconstruction following a partial laryngectomy.

Study Design: Bench and animal research.

Methods: A construct made from a porous polyethylene scaffold shaped in a canine-specific configuration and seeded with autologous canine adipose-derived stem cells in fibrin glue was implanted in a canine following a partial laryngectomy.

Advances in regenerative medicine for otolaryngology/head and neck surgery.

Head and neck structures govern the vital functions of breathing and swallowing. Additionally, these structures facilitate our sense of self through vocal communication, hearing, facial animation, and physical appearance. Loss of these functions can lead to loss of life or greatly affect quality of life.

Aeroacoustic source characterization in a physical model of phonation.

This paper presents measurements conducted in a physical model of the adult human airway. The goals of this work are to (1) benchmark the physical model to excised larynx models in the literature and (2) empirically demonstrate the relationship between vocal fold drag and sound production. Results from the airway model are first benchmarked to published time-averaged behavior of excised larynx models.

Computed Tomography Data to Generate a Reproducible, Anatomically Accurate Hemilaryngeal Model.

Objective: The study aims to demonstrate the reproducibility and feasibility of creating a hemilaryngeal model with a medialized vocal fold (VF) using 3-dimensional (3D) modeling techniques in both healthy larynges and those affected by cancer.

Study Design: Three-dimensional modeling of human larynges.

Setting: Tertiary academic referral center and regenerative medicine laboratory.

An accurate model of polyglutamine.

Polyglutamine repeats in proteins are highly correlated with amyloid formation and neurological disease. To better understand the molecular basis of glutamine repeat diseases, structural analysis of polyglutamine peptides as soluble monomers, oligomers, and insoluble amyloid fibrils is necessary. In this study, fluorescence resonance energy transfer (FRET) experiments and molecular dynamics simulations using different theoretical models of polyglutamine were conducted.