Dynamics and Diagnostic Relevance of Kynurenine Serum Level after Kidney Transplantation.

Background: Inflammatory events after kidney transplantation (Tx) may lead to activation of the tryptophane-catabolizing enzyme indoleamine 2,3-dioxygenase followed by the formation of kynurenine (KYN). Post-transplant KYN serum levels in kidney allograft recipients were analyzed for their diagnostic value.

Material And Methods: This was a retrospective analysis of KYN levels (normal value: 2.

Causes and prognostic value of pre-transplant elevated kynurenine level in kidney allograft recipients.

Background: The activation of the tryptophane catabolizing enzyme Indoleamine 2,3-dioxygenase leads to the formation of kynurenine and other metabolites that counter-regulate immune activation resulting in restoration of immune homeostasis. But in chronic immune activation, as in hemodialysed patients, the immunosuppressive feedback mechanisms continue as indicated by elevated kynurenine concentrations. However, its relevance is still a matter of debate.