Comparison of tendon attachment to 3D printed Ti6Al4V implant versus Trevira® implant: A paired experimental animal study.

Background: Soft-tissue attachment is crucial for the success of megaprosthesis surgery and improvement in current treatment is needed. The aim of this study was to compare the biomechanical and histomorphometric properties of soft-tissue attachment between 3D printed Ti6Al4V implants featuring a 630 μm microporous structure and commercially available Trevira® implants with a 200 μm porous structure in a non-loadbearing ovine model.

Methods: Ten skeletally mature ewes underwent surgical implantation with both implants.

Multidrug resistance protein 1 silencing in osteosarcoma and chondrosarcoma cell lines.

Background: The poor response of metastatic osteo- and chondrosarcomas to chemotherapy could be the result of multidrug resistance (MDR), which may be overcome through the use of small interfering RNA (siRNA). However, several methodologic questions remain unresolved.

Aims: To test the toxicity of three commonly used siRNA transfection reagents and apply the least toxic reagent to investigate the siRNA-induced MDR1 mRNA knockdown.

[Shewanella algae infection after surgical treatment of Haglund's heel and rupture of the Achilles tendon].

This is a case report of soft tissue infection with the marine bacterium Shewanella algae that is rare in Denmark. The patient was a 43-year-old male and he was treated surgically for Haglund's heel, a bony protrusion at the calcaneus. After clinical healing the patient suffered a rupture of the Achilles tendon, which was treated surgically as well.