Publications by authors named "Michael Lerro"
Article Synopsis
- The study examines how genetic factors influence DNA methylation (DNAm), which is crucial for understanding gene regulation and diseases, using data from 32,851 participants.
- Researchers identified genetic variants linked to DNAm at over 420,000 sites and created a database of more than 270,000 independent mQTLs, highlighting the complexity and polygenic nature of DNAm levels.
- The findings suggest that while some shared genetic variants are linked to both DNAm and complex diseases, only a few cases indicate a direct causal relationship, revealing a complicated connection between genetics and phenotypes.
PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses.
Cancer Epidemiol Biomarkers Prev
July 2016
Background: PIWI-interacting RNAs (piRNAs), the largest class of noncoding RNAs in mammals, cooperate with PIWI proteins to safeguard the genome from insertional mutations during germline development. Although a growing number of studies have linked the PIWI-piRNA pathway to carcinogenesis, the role of piRNAs in glioma has not been explored.
Methods: Utilizing directly measured and imputed genotypes from the GliomaScan genome-wide association study (1,840 cases and 2,401 controls), genetic variants in 1,428 piRNAs were analyzed for association with glioma risk.
Well defined hollow iron oxide nanoshells are active, selective and recyclable catalysts for the oxidation of styrene into benzaldehyde using difficult-to-activate molecular oxygen as the sole oxidant. Using no noble metals, unprecedented conversion of 90% was maintained while high selectivity of 73% was able to be achieved.
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