Tetracycline-ferrite nanocomposites formed via high-energy ball milling and the influence of milling conditions.

High-energy ball milling was used to mediate the formation of nanocomposites containing tetracycline and magnetic nanoparticles. Tetracycline-HCl was ball milled for 1, 3, 5, 15, and 30 h under argon or air atmosphere with preformed Mg 0.5 Zn 0.

Predictive models for maximum recommended therapeutic dose of antiretroviral drugs.

A novel method for predicting maximum recommended therapeutic dose (MRTD) is presented using quantitative structure property relationships (QSPRs) and artificial neural networks (ANNs). MRTD data of 31 structurally diverse Antiretroviral drugs (ARVs) were collected from FDA MRTD Database or package inserts. Molecular property descriptors of each compound, that is, molecular mass, aqueous solubility, lipophilicity, biotransformation half life, oxidation half life, and biodegradation probability were calculated from their SMILES codes.

Preparation, spectrochemical, and computational analysis of L-carnosine (2-[(3-aminopropanoyl)amino]-3-(1H-imidazol-5-yl)propanoic acid) and its ruthenium (II) coordination complexes in aqueous solution.

This study reports the synthesis and characterization of novel ruthenium (II) complexes with the polydentate dipeptide, L-carnosine (2-[(3-aminopropanoyl)amino]-3-(1H-imidazol-5-yl)propanoic acid). Mixed-ligand complexes with the general composition [ML(p)(Cl)(q)(H₂O)(r)]·xH₂O (M = Ru(II); L = L-carnosine; p = 3 - q; r = 0-1; and x = 1-3) were prepared by refluxing aqueous solutions of the ligand with equimolar amounts of ruthenium chloride (black-alpha form) at 60 °C for 36 h. Physical properties of the complexes were characterized by elemental analysis, DSC/TGA, and cyclic voltammetry.

Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement.

Saquinavir is an anti-retroviral drug with very low oral bioavailability (e.g. 0.