Spatiotemporal clustering of cases of Kawasaki disease and associated coronary artery aneurysms in Canada.

Detailed epidemiologic examination of the distribution of Kawasaki disease (KD) cases could help elucidate the etiology and pathogenesis of this puzzling condition. Location of residence at KD admission was obtained for patients diagnosed in Canada (excluding Quebec) between March 2004 and March 2015. We identified 4,839 patients, 164 of whom (3.

Environmental epidemiology of Kawasaki disease: Linking disease etiology, pathogenesis and global distribution.

Background: The pathogenesis of Kawasaki disease (KD) is commonly ascribed to an exaggerated immunologic response to an unidentified environmental or infectious trigger in susceptible children. A comprehensive framework linking epidemiological data and global distribution of KD has not yet been proposed.

Methods And Findings: Patients with KD (n = 81) were enrolled within 6 weeks of diagnosis along with control subjects (n = 87).

Epidemiology of Kawasaki Disease in Canada 2004 to 2014: Comparison of Surveillance Using Administrative Data vs Periodic Medical Record Review.

Background: We have previously documented an increase in the incidence of Kawasaki disease (KD) in Ontario followed by a stabilization from 1995 to 2006. We sought to validate the estimation of incidence of KD using administrative data and to describe the epidemiology of KD across Canada from 2004 to 2014.

Methods: We queried the Canadian Hospital Discharge Database for hospital admissions associated with a discharge diagnosis of KD.

Surgical repair of pulmonary artery sling in an adult.

Pulmonary artery sling is a rare congenital vascular anomaly that typically presents in the first month of life with severe respiratory symptoms. In this condition, the left pulmonary artery originates off the right pulmonary artery and courses between the trachea and esophagus, causing compression of both structures. Of those patients with pulmonary artery sling, a small subset survives to adulthood with few or no symptoms.