Publications by authors named "Michael L Prodromou"
Article Synopsis
- The study assessed the effectiveness of 18F-FDG PET imaging in diagnosing spondylodiscitis, a rare infection of the spine, using existing literature.
- Analysis included data from 12 studies with a total of 224 patients, showing a very high sensitivity (97%) and good specificity (88%) for the FDG PET test in identifying the condition.
- The findings indicate that FDG PET, especially with PET/CT technology, is a reliable method for diagnosing spondylodiscitis and is less influenced by factors like metallic implants, providing effective exclusion of the disease.
Background: Toll-like receptor 4 plays a role in pathogen recognition, and common polymorphisms may alter host susceptibility to infectious diseases.
Purpose: To review the association of two common polymorphisms (TLR4 896A>G and TLR4 1196C>T) with infectious diseases.
Data Sources: We searched PubMed and EMBASE up to March 2013 for pertinent literature in English, and complemented search with references lists of eligible studies.
Context: Interleukin-6 (IL-6) is implicated in the pathophysiology of hematologic neoplasia.
Objective: To review the role of IL-6 single nucleotide polymorphisms (SNPs) in hematologic neoplasia.
Methods: PubMed and EMBASE search of genetic association studies.
Ionotropic glutamate receptors (iGluRs), including the NMDA receptor subtype, are ligand-gated ion channels critical to fast signaling in the CNS. NMDA receptors are obligate heterotetramers composed of two GluN1 and typically two GluN2 subunits. However, the arrangement of GluN subunits in functional receptors-whether like subunits are adjacent to (N1/N1/N2/N2) or diagonal to (N1/N2/N1/N2) one another-remains unclear.
View Article and Find Full Text PDFN-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels that contribute to fundamental physiological processes such as learning and memory and, when dysfunctional, to pathophysiological conditions such as neurodegenerative diseases, stroke, and mental illness. NMDARs are obligate heteromultimers typically composed of NR1 and NR2 subunits with the different subunits underlying the functional versatility of NMDARs. To study the contribution of the different subunits to NMDAR channel structure and gating, we compared the effects of cysteine-reactive agents on cysteines substituted in and around the M1, M3, and M4 segments of the NR1 and NR2C subunits.
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