Publications by authors named "Michael L Misel"
Sex plays a role in the incidence and progression of a wide variety of diseases and conditions related to transplantation. Additionally, a growing body of clinical and experimental evidence suggests that sex can impact the pharmacokinetics and pharmacodynamics of several commonly used immunosuppressive and anti-infective drugs in transplant recipients. A better understanding of these sex differences will facilitate advances in individualizing treatment for patients and improve outcomes of solid organ transplantation.
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- Hepatic encephalopathy (HE) is a serious, often reversible brain-related complication that can occur in patients with liver cirrhosis and other metabolic disorders, characterized by cognitive and mood changes, muscle issues, and sleep disturbances.
- Standard treatments like lactulose and rifaximin are commonly used, but they can have side effects and may not work for everyone, creating a need for additional therapies.
- Sodium benzoate is an alternative adjunctive treatment that could help some patients who don't respond to standard therapies, but its benefits are not fully proven, and it may not be suitable for those with specific health issues like kidney dysfunction.