Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from .

Eight monoterpene indole alkaloids (-), including one new picraline-type alkaloid, 2-hydroxyakuammiline () and seven known compounds: akuammigine (), akuammine (), akuammidine (), akuammiline (), akuammiline N-oxide (), akuammiline (), rhazimol (), and alstonine () were isolated from the seeds of . Structure elucidation was done by analysis of their MS and NMR spectroscopic data. The antiplasmodial effects of compounds - were moderate.

Marine-Derived Furanones Targeting Quorum-Sensing Receptors in : Molecular Insights and Potential Mechanisms of Inhibition.

The quorum-sensing (QS) machinery in disease-causing microorganisms is critical in developing antibiotic resistance. In , QS is involved in biofilm formation, virulence factors production, and general tolerance to antimicrobials. Owing to the major role QS plays, interference in the process is probably a facile route to overcome antimicrobial resistance.

Peptide Extract from Red Kidney Beans, (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects.

The rapid spread of multidrug-resistant bacteria has led to an increased risk of infectious diseases. , in particular, poses a significant obstacle due to its propensity to rapidly acquire resistance to conventional antibiotics. This has resulted in an urgent need for the development of new classes of antibiotics that do not induce resistance.

Antimalarial compounds from the climbing stems of .

S Walp., () is used traditionally in West Africa for the treatment of malaria. However, no scientific reports validating these effects and its active constituents are on record.

peptides as potential antimicrobial agents.

The phenomenon of antimicrobial resistance threatens our ability to treat common infections. The clinical pipeline for new antimicrobials is pretty much dry and hence, there is a need for the development of new antimicrobial agents with low toxicities to help fight resistant microorganisms. This work aimed to design antimicrobial peptides with low toxicities using a database filtering technology and evaluate their bioactivities.

Antimalarial, Antioxidant, and Toxicological Evaluation of Extracts of , , , and .

In many parts of the world, malaria undoubtedly poses a serious threat to health care systems. Malaria treatment has increasingly become complicated, primarily due to the emergence of widespread resistance of the malaria parasites to cheap and affordable malaria therapeutics. The use of herbal remedies to treat various ailments, including malaria and malaria-like ailments in Ghana is common.

Antimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants.

The economic costs associated with morbidity and mortality due to malaria and malaria associated complications in many sub-Saharan countries and other malaria endemic regions of the world are huge. Reports of emergence of parasite resistance to current malaria drugs have complicated malaria treatment and require the development of new therapeutic agents. The folkloric use of medicinal plants for the management of malaria is well documented.