Color vision deficiency (CVD) affects a significant portion of the population, yet its impact is often overlooked in medical education, especially in visually demanding specialties like dermatology, pathology, and radiology. In this study, we investigated the potential of ChatGPT to comprehend CVD-simulated images in image-based diagnostic tasks. Notably, the model successfully adapted its diagnostic reasoning to match CVD-modified color perception while preserving high prediction accuracy.
View Article and Find Full Text PDFIn this report, we correlated the incidence of rosacea with coffee (regular and decaffeinated) and tea consumption in a large cohort of middle-aged men and women living within the United Kingdom. Caffeinated coffee drinkers had lower odds for rosacea diagnosis compared to non-coffee drinkers. We hypothesize that the vasoconstrictive effects of caffeine in regular coffee overpower the vasodilatory effects associated with hot beverages and support it to be protective against rosacea.
View Article and Find Full Text PDFBackground: Approximately 85% of melanoma patients who undergo a sentinel lymph node biopsy (SLNB) are node-negative. Melanoma incidence is highest in patients ≥65 years, but their SLNB positivity rate is lower than in younger patients. CP-GEP, a model combining clinicopathologic and gene expression variables, identifies primary cutaneous melanoma (CM) patients who may safely forgo SLNB due to their low risk for nodal metastasis.
View Article and Find Full Text PDFImportance: Alopecia areata (AA) is a complex immune-mediated disorder that causes nonscarring hair loss. Previous reports have documented preferential targeting of pigmented hair follicles with sparing of gray, nonpigmented hair follicles in alopecia lesions. Thus, immune targeting of melanogenesis-associated proteins in melanocytes and keratinocytes represents a potential mechanism for the inflammation that targets anagen hairs in alopecia areata.
View Article and Find Full Text PDFBackground: Data on the impact of biologics and immunomodulators on coronavirus disease 2019 (COVID-19)-related outcomes remain scarce.
Objective: We sought to determine whether patients taking tumor necrosis factor inhibitors (TNFis) or methotrexate are at increased risk of COVID-19-related outcomes.
Methods: In this large comparative cohort study, real-time searches and analyses were performed on adult patients who were diagnosed with COVID-19 and were treated with TNFis or methotrexate compared with those who were not treated.
The autosomal dominant presentation of trichilemmal cysts is one of the most common single gene familial diseases in humans. However, the genetic basis for the inheritance and genesis of these lesions has remained unknown. We first studied patients with multiple trichilemmal cysts using exome and Sanger sequencing.
View Article and Find Full Text PDFThis diagnostic study compares the training efficacy of a novel web-based application to the publicly available Internet Curriculum For Melanoma Early Detection Skin Education Series to determine if intuitive visual diagnosis training is superior to a traditional rule-based algorithm in the diagnosis of melanomas.
View Article and Find Full Text PDFCutaneous meningiomas (CM) are a small subset of meningiomas, further classified into three subtypes. The authors present a 15-year-old male with a symptomatic congenital type I CM and describe the histopathological and immunohistochemical findings. To the authors' knowledge, this is the first report of an extraspinal lumbar type I CM with intradural attachment to the phylum terminale.
View Article and Find Full Text PDFBenign glandular schwannomas are rare and should be distinguished from malignant peripheral nerve sheath tumors with similar divergent tissue differentiation. The authors present a benign glandular schwannoma with ancient change that developed in the subcutis of a 46-year-old man's posterior calf. He lacked stigmata of neurofibromatosis type 1 (NF1).
View Article and Find Full Text PDFJ Invest Dermatol
January 2014
Recent advances in sequencing technology allow genome-scale approaches to cancer mutation discovery. Such data-intensive methods have been applied to cutaneous squamous cell carcinomas (SCCs) and melanomas but have not, to our knowledge, been applied to basal cell carcinomas (BCCs). We used whole-exome sequencing to characterize the mutational landscape of sporadic BCCs.
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