Publications by authors named "Michael Kolf"
Article Synopsis
- A phase I dose escalation study was conducted to evaluate lyso-thermosensitive liposomal doxorubicin (LTLD) in combination with radiofrequency (RF) ablation for liver tumors, focusing on determining the maximum tolerated dose (MTD) and potential side effects.
- The study involved patients with primary or metastatic liver tumors, administering LTLD intravenously prior to RF ablation, assessing different dose levels.
- Results indicated that the MTD for LTLD was 50 mg/m², with manageable toxicity observed such as reversible neutropenia and leukopenia, suggesting this treatment combination warrants further investigation.
Purpose: The physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution was assessed.
Methods: Two bicarbonate-buffered hemofiltration solutions (low- and high-magnesium formulations) were compounded in triplicate. The concentrations of magnesium (15 meq/L) and sodium bicarbonate (50 meq/L) in the high-magnesium formulation were chosen to be somewhat below the concentrations reported as being incompatible in a popular reference.