Variable ventilation versus stepwise lung recruitment manoeuvres for lung recruitment: A comparative study in an experimental model of atelectasis.

Background: Variable ventilation recruits alveoli in atelectatic lungs, but it is unknown how it compares with conventional recruitment manoeuvres.

Objectives: To test whether mechanical ventilation with variable tidal volumes and conventional recruitment manoeuvres have comparable effects on lung function.

Design: Randomised crossover study.

In Silico Study of Local Electrical Impedance Measurements in the Atria - Towards Understanding and Quantifying Dependencies in Human.

Background: Electrical impedance measurements have become an accepted tool for monitoring intracardiac radio frequency ablation. Recently, the long-established generator impedance was joined by novel local impedance measurement capabilities with all electrical circuit terminals being accommodated within the catheter.

Objective: This work aims at in silico quantification of distinct influencing factors that have remained challenges due to the lack of ground truth knowledge and the superposition of effects in clinical settings.

Unmatched ventilation and perfusion measured by electrical impedance tomography predicts the outcome of ARDS.

Background: In acute respiratory distress syndrome (ARDS), non-ventilated perfused regions coexist with non-perfused ventilated regions within lungs. The number of unmatched regions might reflect ARDS severity and affect the risk of ventilation-induced lung injury. Despite pathophysiological relevance, unmatched ventilation and perfusion are not routinely assessed at the bedside.

Regional Lung Perfusion Analysis in Experimental ARDS by Electrical Impedance and Computed Tomography.

Electrical impedance tomography is clinically used to trace ventilation related changes in electrical conductivity of lung tissue. Estimating regional pulmonary perfusion using electrical impedance tomography is still a matter of research. To support clinical decision making, reliable bedside information of pulmonary perfusion is needed.

Influence of background lung tissue conductivity on the cardiosynchronous EIT signal components: a sensitivity study.

Electrical impedance tomography is an accepted and validated tool to analyze and support mechanical ventilation at the bedside. In the future it could furthermore clinically provide information of the pulmonary perfusion and other blood volume changes within the thorax by exploiting a cardiosynchronous EIT component. In the presented study, the spatial forward sensitivity against different background lung tissue distributions was analyzed.