Publications by authors named "Michael Khaigrekht"
Article Synopsis
- Purpose: The study investigates the long-term effects of combining repetitive transcranial magnetic stimulation (rTMS) with cognitive training on brain activity in Alzheimer’s disease (AD) patients, since existing medications have limited impact on slowing cognitive decline.
- Methods: Researchers measured brain electrical activity (EEG) in seven mild AD patients before treatment and after each session during 54 treatment sessions over 4.5 months to assess the effects of rTMS and cognitive training.
- Results: After treatment, there was a significant increase in brain activity (delta) in the temporal region, along with various nonsignificant changes in other brain wave patterns, suggesting potential benefits; higher alpha activity correlated positively with cognitive performance over time,
Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer's disease: a randomized, double-blind study.
J Neural Transm (Vienna)
May 2013
Cortical excitability can be modulated using repetitive transcranial magnetic stimulation (rTMS). Previously, we showed that rTMS combined with cognitive training (rTMS-COG) has positive results in Alzheimer's disease (AD). The goal of this randomized double-blind, controlled study was to examine the safety and efficacy of rTMS-COG in AD.
View Article and Find Full Text PDFPurpose: Obstructive sleep apnea is associated with cognitive impairment, but whether hypoxemia or repeated arousals and sleepiness are the underlying mechanism is controversial. Studies using a wide range of attention and executive functions tests in patients with severe sleep apnea are lacking.
Methods: In a prospective cohort study, 40 patients aged 30-70 years, diagnosed with obstructive sleep apnea (apnea-hypopnea index ≥5) were recruited.
The current drug treatment for Alzheimer's disease (AD) is only partially and temporary effective. Transcranial magnetic stimulation (TMS) is a non-invasive technique that generates an electric current inducing modulation in cortical excitability. In addition, cognitive training (COG) may improve cognitive functions in AD.
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