Imaging Biomarkers and Their Impact on Therapeutic Decision-Making in the Management of Neovascular Age-Related Macular Degeneration.

These recommendations, produced by a group of Canadian retina experts, have been developed to assist both retina specialists and general ophthalmologists in the management of vision-threatening neovascular age-related macular degeneration (nAMD). The recommendations are based on published evidence as well as collective experience and expertise in routine clinical practice. We provide an update on practice principles for optimal patient care, focusing on identified imaging biomarkers, in particular retinal fluid, as well as current and emerging therapeutic approaches.

One-year outcomes of Aflibercept for refractory diabetic macular edema in Bevacizumab nonresponders.

Purpose: A sub-population of patients with diabetic macular edema (DME) responds less effectively to off-label use of Bevacizumab. Approval of Aflibercept for DME has offered Bevacizumab nonresponders an alternative therapeutic option. Herein, we investigate the anatomical and functional changes associated with Aflibercept treatment in Bevacizumab nonresponders with chronic DME in a Canadian setting.

Prognostic factors of postoperative intraretinal cystoid spaces after primary pars plana vitrectomy for vitreomacular traction.

Purpose: To study the anatomical and surgical prognostic factors related to developing postoperative intraretinal cystoid spaces (ICS) six months after 25-gauge pars plana vitrectomy (PPV) for vitreomacular traction (VMT).

Methods: The study is a retrospective case series of patients presenting with VMT treated primarily with PPV. All patients underwent 25-gauge PPV by the same retina surgeon.

Impact of surgical case order on epiretinal membrane peeling surgery.

Objective: To determine whether surgical warm-up affects epiretinal membrane (ERM) peeling complication rates and surgical case times.

Setting: Jewish General Hospital, Montreal, QC, Canada.

Design: Retrospective case-control study.

Disorganization of Retinal Inner Layers and Ellipsoid Zone Disruption Predict Visual Outcomes in Central Retinal Vein Occlusion.

Purpose: To assess the associations and predictive value of spectral-domain (SD) OCT inner and outer retinal structural parameters and visual acuity (VA) outcomes in macular edema (ME) secondary to central retinal vein occlusion (CRVO).

Design: Retrospective, longitudinal cohort study.

Participants: Eighty-four patients with ME secondary to CRVO receiving pro re nata anti-vascular endothelial growth factor (VEGF) therapy at 3 tertiary-level retina referral centers.

EPSTEIN-BARR VIRUS ACUTE RETINAL NECROSIS IN AN IMMUNOCOMPETENT HOST.

Purpose: To describe a case of Epstein-Barr virus (EBV)-associated acute retinal necrosis (ARN) in an immunocompetent patient and to summarize the clinical features of published molecularly confirmed EBV-ARN cases.

Methods: Case report and literature review.

Results: An 83-year-old immunocompetent woman with unilateral ARN presented with visual acuity of light perception.

Ocriplasmin versus vitrectomy for the treatment of macular holes.

Objective: To compare the anatomical and visual outcomes of patients with bilateral macular holes (MH) who have been treated with pars plana vitrectomy in one eye and intravitreal ocriplasmin in the fellow eye.

Design: Multicentre, retrospective case series.

Participants: Twenty-two eyes of 11 patients with bilateral MH treated with vitrectomy in one eye and ocriplasmin in the other were included.

Treatment of cystic cavities in X-linked juvenile retinoschisis: The first sequential cross-over treatment regimen with dorzolamide.

Purpose: To report the first sequential cross-over treatment with the longest ophthalmic follow-up in a case of X-linked juvenile retinoschisis (XLRS) successfully treated with topical dorzolamide.

Observations: A healthy 34 year-old man presented with one month history of decreased visual acuity in his left eye. Funduscopy was significant for a blunted and cystoid-like foveal reflex in both eyes.

Long-term outcomes of sutureless 25-G+ pars-plana vitrectomy for the management of diabetic tractional retinal detachment.

Purpose: To evaluate the short- and long-term surgical and clinical outcomes in eyes with diabetic tractional retinal detachment (TRD) undergoing 25-G+ pars-plana vitrectomy (PPV).

Methods: A total of 238 patients were reviewed for inclusion in this study. A retrospective cohort study of 109 eyes of 73 patients operated on for diabetic TRD were included.

Usefulness of Discarded Vitreous Samples from Routine Vitrectomy.

Purpose. To describe the histopathological features of vitreous samples obtained after vitrectomy surgery from diabetic and nondiabetic patients. Methods.

Spatial judgments in patients with retinitis pigmentosa.

Previous investigations into cortical plasticity in the presence of ocular disease have focused on central retinal damage. Perceptually, patients often report distortions of visual space which can be partially explained by perceptual filling-in. The mechanisms involved could also apply to peripheral field loss.

Beyond visual acuity: functional outcome and patient satisfaction following treatment for age-related macular degeneration.

Objective: The success of current medical treatments for choroidal neovascular membranes secondary to age-related macular degeneration (AMD) has often been determined anatomically by change in lesion size and cessation of leakage. Measuring the functional success of treatments has most often revolved around visual acuity and has seldom encompassed patients' satisfaction with treatment. Using additional objective and subjective measures to assess the outcome of treatments may provide greater insight into the visual functions that are lost, maintained, or improved during the course of treatment.

Management of optic disk pit-associated macular detachment with tisseel fibrin sealant.

Background: Optic disk pit-associated macular detachment is a challenging condition to treat. Many surgical methods have been used to treat this condition with varying degrees of success.

Methods: We managed optic disk pit-associated macular detachment in three cases with pars plana vitrectomy, fluid-air exchange, drainage of subretinal fluid through the optic disk pit, application of Tisseel fibrin sealant (Baxter Healthcare Corporation, CA) to the optic disk pit, C3F8 gas injection, and postoperative prone positioning.

Hierarchical linear modeling of visual acuity change over time: rate of functional recovery after macular hole surgery.

Purpose: To examine acuity recovery rate after Macular Hole (MH) surgery, using Hierarchical Linear Modeling (HLM) with linear and curvilinear regression analysis.

Methods: Preoperative MH diameter (OCT) and acuity (ETDRS) were recorded in 20 eyes. Acuities were tested during follow-up (6 to 23 months), with three to eight measurements per eye.

Preoperative B-scan ultrasonography of the vitreoretinal interface in phakic patients undergoing rhegmatogenous retinal detachment repair and its prognostic significance.

Purpose: To perform ultrasonographic evaluation of the preoperative status of the posterior vitreoretinal interface in phakic patients undergoing surgery for retinal detachment (RD) with flap tear(s) and to investigate its relationship with postoperative anatomic and visual acuity outcomes.

Methods: A prospective, consecutive case series including 50 phakic eyes of 49 patients with retinal detachment and flap tear(s) undergoing retinal detachment surgery by a single vitreoretinal surgeon, who was unaware of the patient's preoperative B-scan ultrasonographic findings. Main outcome measures were comparisons between patients with partial versus complete posterior vitreous detachment (PVD) of primary retinal reattachment rates (retinal reattachment with a single surgical procedure), rates of retinal reattachment at month 12, and visual acuity outcomes at month 12.

Differences between recognition and resolution acuity in patients undergoing macular hole surgery.

Purpose: The present investigation compared recognition acuities (ETDRS chart) with resolution acuities (Landolt-C chart) in a sample of patients with idiopathic macular holes (MH). Traditionally, visual acuity in a clinical setting is measured with a letter chart. Yet, the ability to recognize a letter differs from a resolution task, such as detecting the direction of a gap in a ring.