Publications by authors named "Michael Jay Fisher"
Background: Neurofibromatosis type 1 and neurofibromatosis type 2 are unrelated, distinct genetic disorders characterized by the development of central and peripheral nervous system tumors.
Summary: Neurofibromatosis type 1 is the most common inherited tumor predisposition syndrome with a lifelong increased risk of benign and malignant tumor development, such as glioma and nerve sheath tumors. Neurofibromatosis type 2 classically presents with bilateral vestibular schwannoma, yet it is also associated with non-vestibular schwannoma, meningioma, and ependymoma.
Background: Children with neurofibromatosis type 1 (NF1) are predisposed to both brain tumors and cognitive deficits. While changes in white matter integrity after multimodal therapy are associated with cognitive dysfunction, the effect of isolated chemotherapy in NF1 is unknown. To determine whether chemotherapy is associated with white matter microstructural changes, we examined diffusion tensor imaging (DTI) in NF1 subjects.
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- The study investigates visual acuity loss in children with neurofibromatosis type 1 (NF1)-associated optic pathway gliomas (OPGs), focusing on the relationship between brain tissue microstructure and visual outcomes.
- Researchers examined diffusion tensor imaging (DTI) of optic nerve pathways in 50 children alongside their ophthalmologic evaluations, utilizing multivariate analysis to assess the impact of fiber integrity on vision.
- Findings reveal that decreased fractional anisotropy (FA) in the optic radiations correlates with poorer visual acuity and may help predict future changes in vision for these patients.