Outcome of image-guided biopsies: Retrospective review of the West of Scotland musculoskeletal oncology service.

Introduction: Image-guided needle biopsy of a suspected musculoskeletal malignancy has become increasingly popular as an effective modality for diagnosis. Our aim was to determine accuracy and success rates of the image guided biopsies performed by our service.

Methods: A retrospective review of the Bone and Soft Tissue Sarcoma service database was performed to identify all patients who underwent image guided biopsy and to identify the results of such investigations.

Pigmented villonodular synovitis of the foot and ankle: Forty years of experience from the Scottish bone tumor registry.

Fourteen cases of pigmented villonodular synovitis (PVNS) of the foot and ankle accrued from the Scottish Bone Tumor Registry are presented with an average follow-up of 4.6 years. This study analyzed the clinical, radiological, and histopathological features and investigated their clinical behavior and the factors influencing recurrence.

Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities.

We defined the immunocytochemical expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in benign soft tissue neoplasms, fibromatoses, and sarcomas, together with the activity of gelatinase MMPs and TIMPs measured by zymography and reverse zymography in a subset of cases. The most strongly expressed MMP in all tumors was MMP-1, with weaker expression of MMP-10, MMP-11, and MMP-14 in most tumors. Nuclear expression of MMP-1, MMP-8, and MMP-13 was an unusual feature.

Revision of distal femoral endoprosthetic arthroplasty with impacted morsellized allograft.

We report the use of contained impacted morsellized allograft to revise an aseptically loose, massive distal femoral cemented endoprosthetic replacement in a 27-year-old caucasian woman. The prosthesis was inserted 4 years earlier, following neoadjuvant chemotherapy and resection of a distal femoral high grade osteosarcoma. Impaction grafting was used to restore bone stock and maintain femoral length.