Publications by authors named "Michael James Chambers"
Article Synopsis
- Evolutionary arms races occur between host and viral proteins, where genetic variants are constantly evolving, particularly in proteins like PKR that play a role in the immune response against viruses.
- PKR acts as a detector of viral replication and combats it by inhibiting protein synthesis, but it also faces challenges from viral antagonists that try to disable its function.
- Research into PKR's variants revealed that it has rapidly changing regions that can resist viral antagonists, offering insights into how PKR can adapt and maintain its effectiveness against evolving viral threats.
