Chromosomal rearrangements in PLAG1 of myoepithelial salivary gland tumours.

Unlabelled: PLAG1 mutations are related to the development of pleomorphic adenomas. A specific aspect of PA is the histological diversity of this entity, containing cells with mesenchymal, epithelial and myoepithelial differentiation. Evidence for myoepithelial cells in PA raises the question whether the very rare entity of pure myoepithelial salivary gland tumours shows chromosomal translocations and rearrangements and whether activation of PLAG1 can be detected.

Clinical and immunohistologic typing of salivary duct carcinoma: a report of 50 cases.

Background: Due to the low incidence of salivary duct carcinoma (SDC), only limited data in regard to the biologic behavior of this tumor and its immunohistochemical characteristics are available. The authors analyzed the clinical, molecular, and genetic profile of SDC and identified prognostic factors.

Methods: The follow-up of 50 patients with SDC was obtained and paraffin-embedded tumor samples were examined immunohistochemically.

The use of diathermy scissors in parotid gland surgery.

Objective: To evaluate the benefits, as well as the possible complications, of the use of diathermy scissors in parotid gland surgery.

Design: Prospective study of the surgical procedures of the diathermy scissors and a retrospective comparison with a conventionally treated control group concerning cut-closure time.

Setting: Tertiary care referral academic center.

Extragonadal germ-cell tumor: a rare differential diagnosis of a cervical lump in a young man.

In this case report, we discuss the potential diagnostic difficulty of identifying the cause or origin of a cervical swelling, a clinical situation often encountered in otolaryngology patients. A 30-year-old man came to us with a painless left cervical lump that he had noticed 8 weeks earlier. A series of examinations--including various biopsies, computed tomography, and extensive staging procedures--could not establish the diagnosis.

First report of parotid gland metastasis in multiple enchondromatosis with secondary CHOSA (G-III).

Chondrosarcomas constitute the second-most-frequent malignant bone tumors, representing about 10% of all malignant bone tumors. The most frequent localizations comprise the trunk, pelvis and limbs. Metastatic disease usually occurs in the lung; metastases to other localizations are seen occasionally.

Tumor oxygenation under combined whole-body-hyperthermia and polychemotherapy in a case of recurrent carcinoma of the oral cavity.

Background: Previous studies have reported synergistic effects of combined hyperthermia and chemotherapy and/or irradiation. The discussed underlying mechanism for this effect is an synergistic cytotoxic and radiosensitizing effect of hyperthermia. In addition, tumor blood-flow and, consequently, tumor oxygenation are increased during hyperthermia.