Gutzwiller approximation for indistinguishable interacting Brownian particles on a lattice.

Nonequilibrium Brownian systems can be described using a creation and annihilation operator formalism for classical indistinguishable particles. This formalism has recently been used to derive a many-body master equation for Brownian particles on a lattice with interactions of arbitrary strength and range. One advantage of this formalism is the possibility of using solution methods for analogous many-body quantum systems.

Nonequilibrium master equation for interacting Brownian particles in a deep-well periodic potential.

Employing a creation and annihilation operator formulation, we derive an approximate many-body master equation describing discrete hopping from the more general continuous description of Brownian motion on a deep-well nonequilibrium periodic potential. The many-body master equation describes interactions of arbitrary strength and range arising from a "top-hat" two-body interaction potential. We show that this master equation reduces to the well-known asymmetric simple exclusion process and the zero range process in certain regimes.

Clinical Inquiries: Can CBT effectively treat adult insomnia disorder?

Yes. Cognitive behavioral therapy (CBT) administered individually, in a group setting, or on the internet is effective for treating insomnia in adults compared with control (strength of recommendation [SOR]: A, meta-analyses). CBT is comparable to pharmacotherapy for improving measures of sleep (SOR: A, comparative meta-analysis).

Reconstructing free-energy landscapes for nonequilibrium periodic potentials.

We present a method for reconstructing the free-energy landscape of overdamped Brownian motion on a tilted periodic potential. Our approach exploits the periodicity of the system by using the k-space form of the Smoluchowski equation and we employ an iterative approach to determine the nonequilibrium tilt. We reconstruct landscapes for a number of example potentials to show the applicability of the method to both deep and shallow wells and near-to- and far-from-equilibrium regimes.

Covert verbal mediation in arbitrary matching to sample.

Covert verbal mediation was examined in an arbitrary matching-to-sample (MTS) preparation with a high-verbal group (college students) and a low-verbal group (adults with intellectual disabilities). Arbitrary relations were established between nonsense words, visual symbols, objects, and hand signs. Task difficulty was balanced for the groups based on errors during acquisition.

A mild thermomechanical process for the enzymatic conversion of radiata pine into fermentable sugars and lignin.

Background: Conversion of softwoods into sustainable fuels and chemicals is important for parts of the world where softwoods are the dominant forest species. While they have high theoretical sugar yields, softwoods are amongst the most recalcitrant feedstocks for enzymatic processes, typically requiring both more severe pretreatment conditions and higher enzyme doses than needed for other lignocellulosic feedstocks. Although a number of processes have been proposed for converting softwoods into sugars suitable for fuel and chemical production, there is still a need for a high-yielding, industrially scalable and cost-effective conversion route.

Energy transfer in a molecular motor in the Kramers regime.

We present a theoretical treatment of energy transfer in a molecular motor described in terms of overdamped Brownian motion on a multidimensional tilted periodic potential. The tilt represents a thermodynamic force driving the system out of equilibrium and, for nonseparable potentials, energy transfer occurs between degrees of freedom. For deep potential wells, the continuous theory transforms to a discrete master equation that is tractable analytically.

Tight-binding approach to overdamped Brownian motion on a multidimensional tilted periodic potential.

We present a theoretical treatment of overdamped Brownian motion on a multidimensional tilted periodic potential that is analogous to the tight-binding model of quantum mechanics. In our approach, we expand the continuous Smoluchowski equation in the localized Wannier states of the periodic potential to derive a discrete master equation. This master equation can be interpreted in terms of hopping within and between Bloch bands, and for weak tilting and long times we show that a single-band description is valid.

Optimizing the enzyme loading and incubation time in enzymatic hydrolysis of lignocellulosic substrates.

A mathematical model for costing enzymatic hydrolysis of lignocellulosics is presented. This model is based on three variable parameters describing substrate characteristics and three unit costs for substrate, enzymes and incubation. The model is used to minimize the cost of fermentable sugars, as intermediate products on the route to ethanol or other biorefinery products, by calculating optimized values of enzyme loading and incubation time.

Thermodynamic analysis of a high-yield biochemical process for biofuel production.

This paper presents a thermodynamic analysis of a high-yield biochemical process for biofuel production from lignocelluosic biomass based on a previously proposed process. Unlike the standard biochemical process, which ferments sugar intermediates to ethanol, the process under consideration converts sugars to acetic acid which is esterified and hydrogenated to produce ethanol. This process has a significantly higher yield and produces no carbon dioxide.

The multiple control of verbal behavior.

Amid the novel terms and original analyses in Skinner's Verbal Behavior, the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms convergent multiple control and divergent multiple control. We point out some implications for applied work and discuss examples of the role of multiple control in humor, poetry, problem solving, and recall.

Thermodynamic analysis of lignocellulosic biofuel production via a biochemical process: guiding technology selection and research focus.

The aim of this paper is to present an exergy analysis of bioethanol production process from lignocellulosic feedstock via a biochemical process to asses the overall thermodynamic efficiency and identify the main loss processes. The thermodynamic efficiency of the biochemical process was found to be 35% and the major inefficiencies of this process were identified as: the combustion of lignin for process heat and power production and the simultaneous scarification and co-fermentation process accounting for 67% and 27% of the lost exergy, respectively. These results were also compared with a previous analysis of a thermochemical process for producing biofuel.

Efficiency improvements by geothermal heat integration in a lignocellulosic biorefinery.

In an integrated geothermal biorefinery, low-grade geothermal heat is used as process heat to allow the co-products of biofuel production to become available for higher-value uses. In this paper we consider integrating geothermal heat into a biochemical lignocellulosic biorefinery so that the lignin-enriched residue can be used either as a feedstock for chemicals and materials or for on-site electricity generation. Depending on the relative economic value of these two uses, we can maximize revenue of a biorefinery by judicious distribution of the lignin-enriched residue between these two options.

Scaling laws and technology development strategies for biorefineries and bioenergy plants.

The economies of scale of larger biorefineries or bioenergy plants compete with the diseconomies of scale of transporting geographically distributed biomass to a central location. This results in an optimum plant size that depends on the scaling parameters of the two contributions. This is a fundamental aspect of biorefineries and bioenergy plants and has important consequences for technology development as "bigger is better" is not necessarily true.

Clinical grade production and characterization of a fusion protein comprised of the chemokine CCL2-ligand genetically fused to a mutated and truncated form of the Shiga A1 subunit.

First generation chemokine ligand-Shiga A1 (SA1) fusion proteins (leukocyte population modulators, LPMs) were previously only obtained in small quantities due to the ribosomal inactivating protein properties of the SA1 moiety which inhibits protein synthesis in host cells. We therefore employed 4-aminopyrazolo[3,4-d]-pyrimidine, an inhibitor of Shiga A1, to allow the growth of these cells prior to induction and during the expression phase post-induction with IPTG. Scale-up allowed the production of gram quantities of clinical grade material of the lead candidate, OPL-CCL2-LPM.

The role of naming in stimulus categorization by preschool children.

The purpose of the current study was to assess whether children would categorize pictures when taught the relevant listener and speaker behaviors separately. A category-sort test was used to assess emergent conditional relations. Category-sort trials consisted of looking at (Test 1) or tacting/labeling (Test 2) a sample stimulus and selecting the appropriate comparison stimuli.

The effects of consequence manipulation during functional analysis of problem behavior maintained by negative reinforcement.

Two distinct analytic methods have been used to identify the function of problem behavior. The antecedent-behavior-consequence (ABC) method (Iwata, Dorsey, Slifer, Bauman, & Richman, 1982/1994) includes the delivery of consequences for problem behavior. The AB method (Carr & Durand, 1985) does not include consequence delivery, instead relying exclusively on antecedent conditions to evoke the behavior.

Millimeter- and submillimeter-wave characterization of various fabrics.

Transmission measurements of 14 fabrics are presented in the millimeter-wave and submillimeter-wave electromagnetic regions from 130 GHz to 1.2 THz. Three independent sources and experimental set-ups were used to obtain accurate results over a wide spectral range.

Generalization of relational matching to sample in children: a direct replication.

The ability of preschool age children to perform generalized relational matching to sample tasks with and without an overt mediating stimulus was examined. This experiment was a direct replication of a study by Lowenkron (1984) and examined a behavioral model relevant to complex human behavior that he later came to call joint control. Children were trained to code two-dimensional stimuli with the help of a handheld mediating stimulus.

Emergence of Mands and Tacts of Novel Objects among Preschool Children.

According to Skinner's (1957) analysis of verbal behavior, the mand and the tact are functionally independent verbal operants, each of which is acquired through a unique history of reinforcement. The present study attempted to replicate the findings of Lamarre and Holland (1985), who empirically demonstrated functional independence of mands and tacts in typically developing preschool children. Five children participated.

Evaluating stimulus-stimulus pairing and direct reinforcement in the establishment of an echoic repertoire of children diagnosed with autism.

Many children with autism do not imitate adult vocalizations, an important skill in learning to talk. Pairing adult vocalizations with preferred stimuli has been shown to increase free-operant vocalizations but effects are temporary; thus, direct reinforcement may be necessary to establish durable vocal behaviors. In Experiment 1, directly reinforced echoic responses did not increase following stimulus-stimulus pairings in three children with autism.