Assessing chemotherapy dosing strategies in a spatial cell culture model.

Predicting patient responses to chemotherapy regimens is a major challenge in cancer treatment. Experimental model systems coupled with quantitative mathematical models to calculate optimal dose and frequency of drugs can enable improved chemotherapy regimens. Here we developed a simple approach to track two-dimensional cell colonies composed of chemo-sensitive and resistant cell populations fluorescence microscopy and coupled this to computational model predictions.

Effects of ankle support on lower-extremity functional performance: a meta-analysis.

Unlabelled: Clinicians surmise that the application of external ankle support reduces the ability to perform functional skills and movements, but the outcomes from some of these studies have been inconclusive.

Purpose: To meta-analyze studies regarding the effects of external ankle support on lower-extremity functional performance measures.

Methods: A total of 93 effects from 17 randomized controlled trials utilizing predominantly crossover designs with recreationally active participants and competitive athletes were subjected to a random-effects meta-analysis.